# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4357417 | Binding | Inhibition of human BK alpha/beta4 channel expressed in HEK293T cells assessed as K+ outward current fraction at 10 uM at -80 mV holding potential by whole cell patch clamp method relative to control | Homo sapiens | 7 | ALA4354835 | cell-based format | Scientific Literature | |
2. | ALA4357418 | Binding | Binding affinity to NT-495 fluorophore reagent labelled human BK beta4 (45 to 166 residues) incubated for 30 mins by microscale thermophoresis assay | Homo sapiens | 7 | ALA4354835 | single protein format | Scientific Literature | |
3. | ALA4357429 | Binding | Inhibition of BK alpha/beta-4 in PTZ-stimulated rat hippocampal pyramidal neurons assessed as larger action potential width at 300 pA current injection at -80mV holding potential measured after 10 mins by whole cell current clamp assay | Rattus norvegicus | 3 | ALA4354835 | protein complex format | Scientific Literature | |
4. | ALA4357430 | Binding | Inhibition of BK alpha/beta-4 in PTZ-stimulated rat hippocampal pyramidal neurons assessed as slower decay of after hyperpolarization at 300 pA at -80mV holding potential measured after 10 mins by whole cell current clamp assay | Rattus norvegicus | 3 | ALA4354835 | protein complex format | Scientific Literature | |
5. | ALA4357431 | Binding | Inhibition of BK alpha/beta-4 in PTZ-stimulated rat hippocampal pyramidal neurons assessed as increase in AHP size at 300 pA at -80mV holding potential measured after 10 mins by whole cell current clamp assay | Rattus norvegicus | 3 | ALA4354835 | protein complex format | Scientific Literature | |
6. | ALA4357432 | Functional | Anticonvulsant activity against PTZ-induced epileptic seizure Sprague-Dawley rat model assessed as reduction in mortality rate compound infused into hippocampal region and 10 mins later injected with PTZ and measured for 2 hrs post PTZ-stimulation | Rattus norvegicus | 2 | ALA4354835 | organism-based format | Scientific Literature | |
7. | ALA4357434 | Functional | Anticonvulsant activity against PTZ-induced epileptic seizure Sprague-Dawley rat model assessed as latency time of seizures compound infused into hippocampal region and 10 mins later injected with PTZ and measured for 2 hrs post PTZ-stimulation (Rvb = 108.5 +/- 8.63 sec) | Rattus norvegicus | 4 | ALA4354835 | organism-based format | Scientific Literature | |
8. | ALA4357435 | Functional | Anticonvulsant activity against PTZ-induced epileptic seizure Sprague-Dawley rat model assessed as duration of seizure compound infused into hippocampal region and 10 mins later injected with PTZ and measured for 2 hrs post PTZ-stimulation (Rvb = 376 +/- 76.43 sec) | Rattus norvegicus | 4 | ALA4354835 | organism-based format | Scientific Literature | |
9. | ALA4357436 | Functional | Anticonvulsant activity against PTZ-induced epileptic seizures Sprague-Dawley rat model assessed as decrease in number of seizures at high stage (stage 4 and 5) compound infused into hippocampal region and 10 mins later injected with PTZ and measured for 2 hrs post-PTZ stimulation | Rattus norvegicus | 3 | ALA4354835 | organism-based format | Scientific Literature | |
10. | ALA4357438 | Functional | Effect on neuronal network in PTZ-induced epileptic seizures Sprague-Dawley rat model assessed as lowered PSD at gamma wave band compound infused into hippocampal region and 10 mins later injected with PTZ and measured after 2 hrs by power spectral density analysis | Rattus norvegicus | 3 | ALA4354835 | organism-based format | Scientific Literature | |
11. | ALA4357439 | Functional | Effect on neuronal network in PTZ-induced epileptic seizures Sprague-Dawley rat model assessed as lowered PSD at theta wave band compound infused into hippocampal region and 10 mins later injected with PTZ and measured after 2 hrs by power spectral density analysis | Rattus norvegicus | 3 | ALA4354835 | organism-based format | Scientific Literature | |
12. | ALA4357440 | Functional | Effect on neuronal network in PTZ-induced epileptic seizures Sprague-Dawley rat model assessed as lowered PSD at alpha wave band compound infused into hippocampal region and 10 mins later injected with PTZ and measured after 2 hrs by power spectral density analysis | Rattus norvegicus | 3 | ALA4354835 | organism-based format | Scientific Literature | |
13. | ALA4357441 | Functional | Effect on neuronal network in PTZ-induced epileptic seizures Sprague-Dawley rat model assessed as lowered PSD at delta wave band compound infused into hippocampal region and 10 mins later injected with PTZ and measured after 2 hrs by power spectral density analysis | Rattus norvegicus | 3 | ALA4354835 | organism-based format | Scientific Literature | |
14. | ALA4357442 | Functional | Effect on neuronal network in PTZ-induced epileptic seizures Sprague-Dawley rat model assessed as lowered PSD at beta wave band compound infused into hippocampal region and 10 mins later injected with PTZ and measured after 2 hrs by power spectral density analysis | Rattus norvegicus | 3 | ALA4354835 | organism-based format | Scientific Literature | |
15. | ALA4357444 | Functional | Inhibition of C-Fos expression in PTZ-induced epileptic seizures Sprague-Dawley rat model assessed as inhibition of FLI-positive granular neurons in DG region of contralateral hippocampus at 10 uM compound infused into hippocampal region and 10 mins later injected with PTZ and measured after 2 hrs by immunohistochemistry | Rattus norvegicus | 3 | ALA4354835 | organism-based format | Scientific Literature | |
16. | ALA4357445 | Functional | Inhibition of C-Fos expression in PTZ-induced epileptic seizures Sprague-Dawley rat model assessed as inhibition of FLI-positive pyramidal neurons in CA3 region of ipsilateral hippocampus at 10 uM compound infused into hippocampal region and 10 mins later injected with PTZ and measured after 2 hrs by immunohistochemistry | Rattus norvegicus | 3 | ALA4354835 | organism-based format | Scientific Literature | |
17. | ALA4357446 | Functional | Inhibition of C-Fos expression in PTZ-induced epileptic seizures Sprague-Dawley rat model assessed as inhibition of FLI-positive pyramidal neurons in CA3 region of contralateral hippocampus at 10 uM compound infused into hippocampal region and 10 mins later injected with PTZ and measured after 2 hrs by immunohistochemistry | Rattus norvegicus | 3 | ALA4354835 | organism-based format | Scientific Literature | |
18. | ALA4357450 | Functional | Neuroprotective activity in PTZ-induced epileptic seizure Sprague-Dawley rat model assessed as inhibition of hippocampal destruction by measuring increase in Nissl stained pyramidal neurons in contralateral hippocampus CA1 region compound infused into hippocampal region and 10 mins later injected with PTZ and measured after 3 days by Nissl staining based microscopic analysis | Rattus norvegicus | 3 | ALA4354835 | organism-based format | Scientific Literature | |
19. | ALA4357451 | Functional | Neuroprotective activity in PTZ-induced epileptic seizure Sprague-Dawley rat model assessed as inhibition of hippocampal destruction by measuring increase in Nissl stained pyramidal neurons in contralateral hippocampus CA3 region compound infused into hippocampal region and 10 mins later injected with PTZ and measured after 3 days by Nissl staining based microscopic analysis | Rattus norvegicus | 2 | ALA4354835 | organism-based format | Scientific Literature | |
20. | ALA4357452 | Functional | Neuroprotective activity in PTZ-induced epileptic seizure Sprague-Dawley rat model assessed as inhibition of hippocampal destruction by measuring increase in Nissl stained granular neurons in contralateral hippocampus DG region compound infused into hippocampal region and 10 mins later injected with PTZ and measured after 3 days by Nissl staining based microscopic analysis | Rattus norvegicus | 2 | ALA4354835 | organism-based format | Scientific Literature |