# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4402235 | B | Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by RapidFire high-throughput mass spectrometry assay | Homo sapiens | 74 | ALA4400569 | assay format | Scientific Literature | |
2. | ALA4402237 | A | Half life in mouse liver microsomes at 0.5 mM preincubated for 5 mins followed by NADP addition and measured after LC-MS/MS analysis | Mus musculus | 3 | ALA4400569 | microsome format | Scientific Literature | |
3. | ALA4402238 | B | Inhibition of HPGDS in RBL cells assessed as reduction in A23187-induced PGD2 production preincubated for 30 mins followed by A23187 addition and measured after 30 mins by RapidFire high-throughput mass spectrometry assay | Rattus norvegicus | 2 | ALA4400569 | cell-based format | Scientific Literature | |
4. | ALA4402239 | A | Apparent permeability of the compound at 2.5 uL at pH 7.4 incubated for 3 hrs under shaking condition by PAMPA | 2 | ALA4400569 | assay format | Scientific Literature | ||
5. | ALA4402240 | P | Solubility of the compound in FaSSIF by HPLC analysis | 2 | ALA4400569 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4402241 | A | Terminal half life in mouse | Mus musculus | 2 | ALA4400569 | organism-based format | Scientific Literature | |
7. | ALA4402242 | A | Clearance in iv dosed mouse | Mus musculus | 2 | ALA4400569 | organism-based format | Scientific Literature | |
8. | ALA4402243 | A | Volume of distribution at steady state in mouse | Mus musculus | 2 | ALA4400569 | organism-based format | Scientific Literature | |
9. | ALA4402244 | A | Oral bioavailability in mouse | Mus musculus | 2 | ALA4400569 | organism-based format | Scientific Literature | |
10. | ALA4402245 | A | Dose normalized AUC in po dosed mouse | Mus musculus | 2 | ALA4400569 | organism-based format | Scientific Literature |