# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4478464 | B | Inhibition of full length recombinant Pim-1 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue preincubated for 30 mins followed by substrate addition for 1 hr by HTRF assay | Homo sapiens | 26 | ALA4477213 | single protein format | Scientific Literature | |
2. | ALA4478465 | B | Inhibition of full length recombinant Pim-2 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue preincubated for 30 mins followed by substrate addition for 1 hr by HTRF assay | Homo sapiens | 26 | ALA4477213 | single protein format | Scientific Literature | |
3. | ALA4478466 | B | Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 mins by flow cytometry | Homo sapiens | 26 | ALA4477213 | cell-based format | Scientific Literature | |
4. | ALA4478467 | A | Intrinsic clearance in rat liver microsomes at 1 uM after 30 mins in presence of NADPH | Rattus norvegicus | 17 | ALA4477213 | microsome format | Scientific Literature | |
5. | ALA4478468 | A | Intrinsic clearance in human liver microsomes at 1 uM after 30 mins in presence of NADPH | Homo sapiens | 17 | ALA4477213 | microsome format | Scientific Literature | |
6. | ALA4478469 | A | Clearance in rat at 2 mg/kg, iv | Rattus norvegicus | 17 | ALA4477213 | organism-based format | Scientific Literature | |
7. | ALA4478470 | A | Volume of distribution at steady state in rat at 2 mg/kg, iv or 5 mg/kg, po | Rattus norvegicus | 17 | ALA4477213 | organism-based format | Scientific Literature | |
8. | ALA4478471 | A | Half life in rat at 2 mg/kg, iv or 5 mg/kg, po | Rattus norvegicus | 17 | ALA4477213 | organism-based format | Scientific Literature | |
9. | ALA4478472 | A | Oral bioavailability in rat at 5 mg/kg | Rattus norvegicus | 17 | ALA4477213 | organism-based format | Scientific Literature |