#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4310452	F	Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobilization preincubated for 2.3 mins followed by glutamate addition and measured after 1.7 mins by Fluo-4-AM dye based fluorescence assay	Rattus norvegicus	37	ALA4308859	cell-based format	Scientific Literature
2.	ALA4310453	F	Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobilization at 30 uM preincubated for 2.3 mins followed by glutamate addition and measured after 1.7 mins by Fluo-4-AM dye based fluorescence assay relative to control	Rattus norvegicus	32	ALA4308859	cell-based format	Scientific Literature
3.	ALA4310454	A	Fraction unbound in rat plasma after 4 hrs by equilibrium dialysis method	Rattus norvegicus	10	ALA4308859	cell-free format	Scientific Literature
4.	ALA4310455	A	Fraction unbound in human plasma after 4 hrs by equilibrium dialysis method	Homo sapiens	10	ALA4308859	cell-free format	Scientific Literature
5.	ALA4310456	A	Fraction unbound in rat brain	Rattus norvegicus	10	ALA4308859	tissue-based format	Scientific Literature
6.	ALA4310457	A	Brain to plasma partition coefficient, Kp of the compound in Sprague-Dawley rat at 0.2 mg/kg, iv administered as cassette dose by LC-MS/MS analysis	Rattus norvegicus	14	ALA4308859	organism-based format	Scientific Literature
7.	ALA4310458	A	Unbound brain to plasma ratio in Sprague-Dawley rat at 0.2 mg/kg, iv administered as cassette dose by LC-MS/MS analysis	Rattus norvegicus	14	ALA4308859	organism-based format	Scientific Literature
8.	ALA4310459	A	Plasma clearance in Sprague-Dawley rat at 0.2 mg/kg, iv administered as cassette dose by LC-MS/MS analysis	Rattus norvegicus	3	ALA4308859	organism-based format	Scientific Literature
9.	ALA4310460	A	Half life in Sprague-Dawley rat at 0.2 mg/kg, iv administered as cassette dose by LC-MS/MS analysis	Rattus norvegicus	3	ALA4308859	organism-based format	Scientific Literature
10.	ALA4310461	A	Volume of distribution at steady state in Sprague-Dawley rat at 0.2 mg/kg, iv administered as cassette dose by LC-MS/MS analysis	Rattus norvegicus	3	ALA4308859	organism-based format	Scientific Literature
11.	ALA4310465	F	Negative allosteric modulation of rat mGlu3R expressed in Trex cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobilization preincubated for 2.3 mins followed by glutamate addition and measured after 2.6 mins by Fluo-4-AM dye based fluorescence assay	Rattus norvegicus	2	ALA4308859	cell-based format	Scientific Literature
12.	ALA4310466	F	Negative allosteric modulation of human mGlu1R expressed in Trex293 cells assessed as decrease in glutamate-induced calcium mobilization preincubated for 2.3 mins followed by glutamate addition and measured after 2.6 mins by Fluo-4-AM dye based fluorescence assay	Homo sapiens	2	ALA4308859	cell-based format	Scientific Literature
13.	ALA4310467	F	Negative allosteric modulation of human mGlu5R expressed in Trex293 cells assessed as decrease in glutamate-induced calcium mobilization preincubated for 2.3 mins followed by glutamate addition and measured after 2.6 mins by Fluo-4-AM dye based fluorescence assay	Homo sapiens	2	ALA4308859	cell-based format	Scientific Literature
14.	ALA4310468	B	Negative allosteric modulation of rat mGlu4 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux preincubated for 2.3 mins followed by glutamate addition measured after 2.6 mins by BTC-AM-dye based fluorescence assay	Rattus norvegicus	2	ALA4308859	cell-based format	Scientific Literature
15.	ALA4310469	B	Negative allosteric modulation of human mGlu6 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux preincubated for 2.3 mins followed by glutamate addition measured after 2.6 mins by BTC-AM-dye based fluorescence assay	Homo sapiens	2	ALA4308859	cell-based format	Scientific Literature
16.	ALA4310470	B	Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring GIRK assessed as reduction in LPA4-induced thallium flux preincubated for 2.3 mins followed by LPA4 addition measured after 2.6 mins by BTC-AM-dye based fluorescence assay	Rattus norvegicus	2	ALA4308859	cell-based format	Scientific Literature
17.	ALA4310471	B	Negative allosteric modulation of rat mGlu8 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux preincubated for 2.3 mins followed by glutamate addition measured after 2.6 mins by BTC-AM-dye based fluorescence assay	Rattus norvegicus	2	ALA4308859	cell-based format	Scientific Literature
18.	ALA4310472	A	Cmax in Sprague-Dawley rat plasma at 10 mg/kg, ip by LC-MS/MS analysis	Rattus norvegicus	1	ALA4308859	organism-based format	Scientific Literature
19.	ALA4310473	A	AUC in Sprague-Dawley rat plasma at 10 mg/kg, ip by LC-MS/MS analysis	Rattus norvegicus	1	ALA4308859	organism-based format	Scientific Literature
20.	ALA4310474	A	Cmax in Sprague-Dawley rat brain at 10 mg/kg, ip by LC-MS/MS analysis	Rattus norvegicus	1	ALA4308859	organism-based format	Scientific Literature