| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4339622 | B | Negative allosteric modulation of recombinant rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current response at -40 mV holding potential by two-electrode voltage clamp method | Rattus norvegicus | 15 | ALA4339195 | cell-based format | Scientific Literature | |
| 2. | ALA4339624 | B | Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current response at -40 mV holding potential by two-electrode voltage clamp method | Rattus norvegicus | 17 | ALA4339195 | cell-based format | Scientific Literature | |
| 3. | ALA4339625 | B | Negative allosteric modulation of recombinant rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current response at 30 uM at -40 mV holding potential by two-electrode voltage clamp method relative to glutamate/glycine | Rattus norvegicus | 12 | ALA4339195 | cell-based format | Scientific Literature | |
| 4. | ALA4339626 | B | Potency index, ratio of NP11999 IC50 to test compound IC50 for negative allosteric modulation of recombinant rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current response | Rattus norvegicus | 3 | ALA4339195 | cell-based format | Scientific Literature | |
| 5. | ALA4339627 | B | Potency index, ratio of NP11999 IC50 to test compound IC50 for negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current response | Rattus norvegicus | 3 | ALA4339195 | cell-based format | Scientific Literature | |
| 6. | ALA4339628 | B | Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current response at 30 uM at -40 mV holding potential by two-electrode voltage clamp method relative to glutamate/glycine | Rattus norvegicus | 12 | ALA4339195 | cell-based format | Scientific Literature | |
| 7. | ALA4339632 | B | Negative allosteric modulation of recombinant rat GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current response at -40 mV holding potential by two-electrode voltage clamp method | Rattus norvegicus | 4 | ALA4339195 | cell-based format | Scientific Literature | |
| 8. | ALA4339633 | B | Negative allosteric modulation of recombinant rat GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current response at 30 uM at -40 mV holding potential by two-electrode voltage clamp method relative to glutamate/glycine | Rattus norvegicus | 3 | ALA4339195 | cell-based format | Scientific Literature | |
| 9. | ALA4339634 | B | Negative allosteric modulation of recombinant rat GluN1/GluN2B expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current response at -40 mV holding potential by two-electrode voltage clamp method | Rattus norvegicus | 1 | ALA4339195 | cell-based format | Scientific Literature | |
| 10. | ALA4339635 | B | Negative allosteric modulation of recombinant rat GluN1/GluN2B expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current response at 30 uM at -40 mV holding potential by two-electrode voltage clamp method relative to glutamate/glycine | Rattus norvegicus | 1 | ALA4339195 | cell-based format | Scientific Literature | |
| 11. | ALA4339636 | B | Negative allosteric modulation of recombinant rat GluA1 expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced current response at 30 uM at -40 mV holding potential by two-electrode voltage clamp method relative to glutamate alone | Rattus norvegicus | 2 | ALA4339195 | cell-based format | Scientific Literature | |
| 12. | ALA4339637 | B | Negative allosteric modulation of human GluA2 R607Q mutant expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced current response at 30 uM at -40 mV holding potential by two-electrode voltage clamp method relative to glutamate alone | Homo sapiens | 2 | ALA4339195 | cell-based format | Scientific Literature | |
| 13. | ALA4339638 | B | Negative allosteric modulation of human GluA3 L513Y mutant expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced current response at 30 uM at -40 mV holding potential by two-electrode voltage clamp method relative to glutamate alone | Homo sapiens | 2 | ALA4339195 | cell-based format | Scientific Literature | |
| 14. | ALA4339639 | B | Negative allosteric modulation of human GluA4 L505Y mutant expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced current response at 30 uM at -40 mV holding potential by two-electrode voltage clamp method relative to glutamate alone | Homo sapiens | 2 | ALA4339195 | cell-based format | Scientific Literature | |
| 15. | ALA4339640 | B | Negative allosteric modulation of rat GluK2 expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced current response at 30 uM at -40 mV holding potential in presence of concanavalin A by two-electrode voltage clamp method relative to glutamate alone | Rattus norvegicus | 2 | ALA4339195 | cell-based format | Scientific Literature | |
| 16. | ALA4339641 | B | Negative allosteric modulation of human P2X expressed in Xenopus laevis oocytes assessed as inhibition of ATP-induced current response at 30 uM at -40 mV holding potential by two-electrode voltage clamp method relative to ATP alone | Homo sapiens | 1 | ALA4339195 | cell-based format | Scientific Literature | |
| 17. | ALA4339642 | B | Negative allosteric modulation of rat GABAA alpha1beta2gamma2S expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current response at 30 uM at -40 mV holding potential by two-electrode voltage clamp method relative to GABA alone | Rattus norvegicus | 2 | ALA4339195 | cell-based format | Scientific Literature | |
| 18. | ALA4339643 | B | Negative allosteric modulation of rat GABAA rho expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current response at 30 uM at -40 mV holding potential by two-electrode voltage clamp method relative to GABA alone | Rattus norvegicus | 2 | ALA4339195 | cell-based format | Scientific Literature | |
| 19. | ALA4339644 | B | Negative allosteric modulation of rat glycine alpha1 expressed in Xenopus laevis oocytes assessed as inhibition of glycine-induced current response at 30 uM at -40 mV holding potential by two-electrode voltage clamp method relative to glycine alone | Rattus norvegicus | 2 | ALA4339195 | cell-based format | Scientific Literature | |
| 20. | ALA4339645 | B | Negative allosteric modulation of rat 5HT3A expressed in Xenopus laevis oocytes assessed as inhibition of serotonin-induced current response at 30 uM at -40 mV holding potential by two-electrode voltage clamp method relative to serotonin alone | Rattus norvegicus | 2 | ALA4339195 | cell-based format | Scientific Literature |
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