# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4410464 | T | Toxicity in BALB/cA mouse assessed as reduction in body weight at 100 mg/kg, po administered bid for 5 days | Mus musculus | 2 | ALA4406889 | organism-based format | Scientific Literature | |
2. | ALA4410465 | B | Inhibition of mouse His-tagged ACC1 expressed in baculovirus infected SF9 cells using acetyl-CoA as substrate incubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry | Mus musculus | 2 | ALA4406889 | cell-based format | Scientific Literature | |
3. | ALA4410466 | B | Inhibition of mouse His-tagged ACC2 expressed in baculovirus infected SF9 cells using acetyl-CoA as substrate incubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry | Mus musculus | 2 | ALA4406889 | cell-based format | Scientific Literature | |
4. | ALA4410467 | B | Inhibition of recombinant human His-tagged ACC1 expressed in baculovirus infected SF9 cells using acetyl-CoA as substrate incubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry | Homo sapiens | 4 | ALA4406889 | cell-based format | Scientific Literature | |
5. | ALA4410468 | B | Inhibition of recombinant human His-tagged ACC2 expressed in baculovirus infected SF9 cells using acetyl-CoA as substrate incubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry | Homo sapiens | 4 | ALA4406889 | cell-based format | Scientific Literature | |
6. | ALA4410469 | B | Selectivity index, ratio of IC50 for recombinant human His-tagged ACC2 expressed in baculovirus infected SF9 cells to IC50 for recombinant human His-tagged ACC1 expressed in baculovirus infected SF9 cells | Homo sapiens | 4 | ALA4406889 | cell-based format | Scientific Literature | |
7. | ALA4410470 | B | Inhibition of recombinant human His-tagged ACC1 expressed in baculovirus infected SF9 cells at 10 uM using acetyl-CoA as substrate incubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry relative to control | Homo sapiens | 2 | ALA4406889 | cell-based format | Scientific Literature | |
8. | ALA4410471 | B | Inhibition of recombinant human His-tagged ACC2 expressed in baculovirus infected SF9 cells at 10 uM using acetyl-CoA as substrate incubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry relative to control | Homo sapiens | 2 | ALA4406889 | cell-based format | Scientific Literature | |
9. | ALA4410472 | P | Solubility of compound at pH 6.8 | 1 | ALA4406889 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4410473 | A | Permeability of compound at pH 5 by PAMPA assay | 2 | ALA4406889 | assay format | Scientific Literature | ||
11. | ALA4410474 | A | Metabolic stability in human Liver microsomes | Homo sapiens | 2 | ALA4406889 | microsome format | Scientific Literature | |
12. | ALA4410475 | A | Metabolic stability in mouse Liver microsomes | Mus musculus | 2 | ALA4406889 | microsome format | Scientific Literature | |
13. | ALA4410476 | A | Inhibition of CYP2C8 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA4406889 | single protein format | Scientific Literature | |
14. | ALA4410477 | A | Inhibition of CYP2C9 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA4406889 | single protein format | Scientific Literature | |
15. | ALA4410478 | A | Inhibition of CYP2D6 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA4406889 | single protein format | Scientific Literature | |
16. | ALA4410479 | A | Inhibition of CYP3A4 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA4406889 | single protein format | Scientific Literature | |
17. | ALA4410480 | A | Cmax in ICR mouse at 0.1 mg/kg, iv | Mus musculus | 2 | ALA4406889 | organism-based format | Scientific Literature | |
18. | ALA4410481 | A | AUC (0 to 8 hrs) in ICR mouse at 1 mg/kg, po | Mus musculus | 2 | ALA4406889 | organism-based format | Scientific Literature | |
19. | ALA4410482 | A | MRT in ICR mouse at 1 mg/kg, po | Mus musculus | 2 | ALA4406889 | organism-based format | Scientific Literature | |
20. | ALA4410483 | A | Half life in ICR mouse at 0.1 mg/kg, iv | Mus musculus | 2 | ALA4406889 | organism-based format | Scientific Literature |