| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4351237 | A | Inhibition of CYP450 assessed as maximum reduction in metabolite formation using coumarin based substrate by fluorescence assay | Homo sapiens | 4 | protein format | Scientific Literature | ||
| 2. | ALA4351239 | A | Inhibition of COX-2 in human whole blood assessed as reduction in LPS-stimulated prostaglandin E2 production preincubated for 15 mins followed by LPS stimulation and measured after overnight incubation by EIA | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 3. | ALA4351240 | A | Inhibition of COX-1 in human whole blood assessed as reduction in calcium ionophore-stimulated thromboxane B2 production preincubated for 30 mins followed by calcium ionophore stimulation and measured after 20 mins by EIA | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 4. | ALA4351241 | A | Selectivity ratio of inhibition of COX-1 in human whole blood to Inhibition of 5-lipoxygenase (unknown origin) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 5. | ALA4351242 | A | Selectivity ratio of inhibition of COX-2 in human whole blood to Inhibition of 5-lipoxygenase (unknown origin) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 6. | ALA4351243 | T | Genotoxicity in mouse L5178Y cells by micronucleus Assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4351244 | A | Agonist activity at AhR in human HepG2 cells assessed as induction of CYP1A1 activity at 0.001 to 30 uM measured after 24 hrs by immunocytochemistry analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4351245 | A | Inhibition of recombinant human BSEP expressed in baculovirus infected Sf21 insect cell vesicles assessed as reduction in NBD-taurocholate uptake by fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4351246 | A | Inhibition of phospholipidosis in rat H42EC3 cells assessed as reduction in NBD-PE accumulation by SYTOX orange staining-based high content imaging analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4351247 | A | Inhibition of Sprague-Dawley rat Mrp2 expressed in baculovirus infected Sf21 insect cell vesicles assessed as reduction in CDF uptake by fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4351248 | P | Distribution coefficient between octanol and sodium phosphate buffer, logD of the compound in pH 7.4 buffer by LC-MS/MS-based shake flask method | 30 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA4351249 | B | Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by scintillation counting method | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 13. | ALA4351251 | B | Inhibition of FLAP in human whole blood assessed as reduction in calcium ionophore-stimulated LTB4 production preincubated for 30 mins followed by calcium ionophore stimulation and measured after 20 mins by EIA | Homo sapiens | 27 | tissue-based format | Scientific Literature | ||
| 14. | ALA4351253 | P | Aqueous solubility in pH 7.4 phosphate buffer after 24 hrs by UPLC/MS/MS analysis | 16 | small-molecule physicochemical format | Scientific Literature | |||
| 15. | ALA4351257 | A | Intrinsic clearance in cryopreserved human hepatocytes assessed as per million cells at 1 uM measured up to 60 mins by LC-MS/MS analysis | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 16. | ALA4351258 | A | Apparent permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 17. | ALA4351259 | A | Glutathione reactivity in human liver microsomes assessed as GSH-compound adduct formation in presence of NADPH by QTOF-MS analysis | Homo sapiens | 16 | microsome format | Scientific Literature | ||
| 18. | ALA4351260 | A | Ketone reactivity in human liver microsomes assessed as methoxylamine-compound adduct formation in presence of NADPH by QTOF-MS analysis | Homo sapiens | 16 | microsome format | Scientific Literature | ||
| 19. | ALA4351261 | A | Drug metabolism in human liver microsomes assessed as contribution of CYP3A4 in drug metabolism | Homo sapiens | 16 | microsome format | Scientific Literature | ||
| 20. | ALA4351262 | A | Drug metabolism in cryopreserved human hepatocytes assessed as CYP3A4-mediated fraction metabolized with and without ketoconazole at 1 uM measured up to 180 mins relative to control | Homo sapiens | 16 | cell-based format | Scientific Literature |
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