#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4339649	Binding	Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced response preincubated for 5 mins followed by glutamate/glycine addition and measured after 5 mins by calcium 5 dye based FLIPR TETRA analysis	Homo sapiens	33	ALA4339196	cell-based format	Scientific Literature
2.	ALA4339656	Binding	Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor measured after 2 hrs by liquid scintillation counting analysis	Rattus norvegicus	27	ALA4339196	assay format	Scientific Literature
3.	ALA4339657	ADME	Extraction ratio in human liver microsomes at 1 uM measured up to 60 mins in presence of NADPH by LC/MS/MS analysis	Homo sapiens	25	ALA4339196	microsome format	Scientific Literature
4.	ALA4339659	ADME	Inhibition of CYP2C19 in human liver microsomes	Homo sapiens	22	ALA4339196	microsome format	Scientific Literature
5.	ALA4339664	ADME	Extraction ratio in rat liver microsomes at 1 uM measured up to 60 mins in presence of NADPH by LC/MS/MS analysis	Rattus norvegicus	25	ALA4339196	microsome format	Scientific Literature
6.	ALA4339665	Binding	Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysis	Homo sapiens	30	ALA4339196	cell-based format	Scientific Literature
7.	ALA4339666	ADME	Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral side in MDCK-MDR1 cells at 5 uM after 60 mins by LC-MS/MS analysis	Canis lupus familiaris	17	ALA4339196	cell-based format	Scientific Literature
8.	ALA4339667	ADME	Clearance in Sprague-Dawley rat at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis	Rattus norvegicus	5	ALA4339196	organism-based format	Scientific Literature
9.	ALA4339668	ADME	Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis	Rattus norvegicus	5	ALA4339196	organism-based format	Scientific Literature
10.	ALA4339669	ADME	Cmax in Sprague-Dawley rat at 5 mg/kg, po administered as single dose by LC-MS/MS analysis	Rattus norvegicus	5	ALA4339196	organism-based format	Scientific Literature
11.	ALA4339670	ADME	AUC (infinity) in Sprague-Dawley rat at 5 mg/kg, po administered as single dose by LC-MS/MS analysis	Rattus norvegicus	5	ALA4339196	organism-based format	Scientific Literature
12.	ALA4339671	ADME	Tmax in Sprague-Dawley rat at 5 mg/kg, po administered as single dose by LC-MS/MS analysis	Rattus norvegicus	5	ALA4339196	organism-based format	Scientific Literature
13.	ALA4339672	ADME	Clearance in rat liver microsomes at 1 uM measured up to 60 mins in presence of NADPH by LC/MS/MS analysis	Rattus norvegicus	2	ALA4339196	microsome format	Scientific Literature
14.	ALA4339673	Functional	Ex vivo receptor occupancy at GluN2B receptor in Sprague-Dawley rat brain assessed as reduction in 3-[3H] 1-(azetidin-1-yl)-2-[6-(4-fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyridin-1-yl]ethanone receptor labeling at 10 mg/kg, po measured after 0.25 hrs by autoradiography	Rattus norvegicus	4	ALA4339196	organism-based format	Scientific Literature
15.	ALA4339674	Functional	Ex vivo receptor occupancy at GluN2B receptor in Sprague-Dawley rat brain assessed as reduction in 3-[3H] 1-(azetidin-1-yl)-2-[6-(4-fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyridin-1-yl]ethanone receptor labeling at 10 mg/kg, po measured after 0.5 hrs by autoradiography	Rattus norvegicus	4	ALA4339196	organism-based format	Scientific Literature
16.	ALA4339675	Functional	Ex vivo receptor occupancy at GluN2B receptor in Sprague-Dawley rat brain assessed as reduction in 3-[3H] 1-(azetidin-1-yl)-2-[6-(4-fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyridin-1-yl]ethanone receptor labeling at 10 mg/kg, po measured after 2 hrs by autoradiography	Rattus norvegicus	4	ALA4339196	organism-based format	Scientific Literature
17.	ALA4339676	ADME	Tmax in Sprague-Dawley rat brain at 10 mg/kg, po by LC-MS/MS analysis	Rattus norvegicus	4	ALA4339196	organism-based format	Scientific Literature
18.	ALA4339678	ADME	Cmax in Sprague-Dawley rat brain at 10 mg/kg, po by LC-MS/MS analysis	Rattus norvegicus	4	ALA4339196	organism-based format	Scientific Literature
19.	ALA4339683	ADME	Glutathione reactivity in human liver microsomes assessed as +GSH-2H+O2 adduct formation at 10 uM measured after 60 mins by LC-MS/MS analysis	Homo sapiens	5	ALA4339196	microsome format	Scientific Literature
20.	ALA4339684	ADME	Glutathione reactivity in human liver microsomes assessed as +GSH-2H+O-CH2 adduct formation at 10 uM measured after 60 mins by LC-MS/MS analysis	Homo sapiens	5	ALA4339196	microsome format	Scientific Literature