# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4426968 | ADME | Cytotoxicity against HIV1 infected human PBMC cells assessed as reduction in cell viability after 7 days by MTT assay | Homo sapiens | 12 | ALA4425139 | cell-based format | Scientific Literature | |
2. | ALA4426969 | ADME | Cytotoxicity against HIV1 infected human CEM cells assessed as reduction in cell viability after 7 days by MTT assay | Homo sapiens | 12 | ALA4425139 | cell-based format | Scientific Literature | |
3. | ALA4426970 | ADME | Cytotoxicity against HIV1 infected African green monkey Vero cells assessed as reduction in cell viability after 7 days by MTT assay | Chlorocebus sabaeus | 12 | ALA4425139 | cell-based format | Scientific Literature | |
4. | ALA4426971 | Binding | Inhibition of HIV1 RT using 17-mer DNA/Alexa Fluor 488 5'-end labeled DNA/Alexa Fluor 555-aha-dUTP as primer/template/substrate preincubated for 10 mins followed substarte addition measured after 30 mins by FRET assay | Human immunodeficiency virus 1 | 17 | ALA4425139 | single protein format | Scientific Literature | |
5. | ALA4426972 | Functional | Antiviral activity against HIV-1 LAI infected in human PBM cells after 7 days | Human immunodeficiency virus 1 | 15 | ALA4425139 | organism-based format | Scientific Literature | |
6. | ALA4426973 | Binding | Inhibition of HIV1 RT using A5'-end 32P-labeled 24-mer primer/a48-mer template preincubated for 5 mins followed by 10 uM nucleotides addition measured after 5 mins by gel-based primer extension assay | Human immunodeficiency virus 1 | 1 | ALA4425139 | single protein format | Scientific Literature | |
7. | ALA4426974 | Binding | Inhibition of HIV1 RT using A5'-end 32P-labeled 24-mer primer/a48-mer template preincubated for 5 mins followed by 25 uM nucleotides addition measured after 2 mins by gel-based primer extension assay | Human immunodeficiency virus 1 | 1 | ALA4425139 | single protein format | Scientific Literature | |
8. | ALA4426975 | Binding | Inhibition of HIV1 RT using A5'-end 32P-labeled 24-mer primer/a48-mer template preincubated for 5 mins followed by 1 uM nucleotides addition measured after 10 mins by gel-based primer extension assay | Human immunodeficiency virus 1 | 1 | ALA4425139 | single protein format | Scientific Literature | |
9. | ALA4426976 | Binding | Inhibition of HIV1 RT using A5'-end 32P-labeled 24-mer primer/a48-mer template preincubated for 5 mins followed by 0.5 uM nucleotides addition measured after 15 mins by gel-based primer extension assay | Human immunodeficiency virus 1 | 1 | ALA4425139 | single protein format | Scientific Literature | |
10. | ALA4426977 | Binding | Inhibition of HIV1 RT K103N mutant using 17-mer DNA/Alexa Fluor 488 5'-end labeled DNA/Alexa Fluor 555-aha-dUTP as primer/template/substrate preincubated for 10 mins followed substarte addition measured after 30 mins by FRET assay | Human immunodeficiency virus 1 | 4 | ALA4425139 | single protein format | Scientific Literature | |
11. | ALA4426978 | Binding | Ratio of IC50 for HIV1 RT K103N mutant to IC50 for wild type HIV1 RT | Human immunodeficiency virus 1 | 3 | ALA4425139 | assay format | Scientific Literature | |
12. | ALA4426979 | Binding | Inhibition of HIV1 RT V108I mutant using 17-mer DNA/Alexa Fluor 488 5'-end labeled DNA/Alexa Fluor 555-aha-dUTP as primer/template/substrate preincubated for 10 mins followed substarte addition measured after 30 mins by FRET assay | Human immunodeficiency virus 1 | 4 | ALA4425139 | single protein format | Scientific Literature | |
13. | ALA4426980 | Binding | Inhibition of HIV1 RT E138K using 17-mer DNA/Alexa Fluor 488 5'-end labeled DNA/Alexa Fluor 555-aha-dUTP as primer/template/substrate preincubated for 10 mins followed substarte addition measured after 30 mins by FRET assay | Human immunodeficiency virus 1 | 4 | ALA4425139 | single protein format | Scientific Literature | |
14. | ALA4426981 | Binding | Ratio of IC50 for HIV1 RT E138K mutant to IC50 for wild type HIV1 RT | Human immunodeficiency virus 1 | 3 | ALA4425139 | assay format | Scientific Literature | |
15. | ALA4426982 | Binding | Inhibition of HIV1 RT Y181C mutant using 17-mer DNA/Alexa Fluor 488 5'-end labeled DNA/Alexa Fluor 555-aha-dUTP as primer/template/substrate preincubated for 10 mins followed substarte addition measured after 30 mins by FRET assay | Human immunodeficiency virus 1 | 4 | ALA4425139 | single protein format | Scientific Literature | |
16. | ALA4426983 | Binding | Ratio of IC50 for HIV1 RT Y181C mutant to IC50 for HIV1 wild type RT | Human immunodeficiency virus 1 | 3 | ALA4425139 | assay format | Scientific Literature | |
17. | ALA4426984 | Unassigned | Ratio of CC50 for human PBM cells to EC50 for HIV-1 LAI infected in human PBM cells | 10 | ALA4425139 | cell-based format | Scientific Literature |