| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4339649 | Binding | Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced response preincubated for 5 mins followed by glutamate/glycine addition and measured after 5 mins by calcium 5 dye based FLIPR TETRA analysis | Homo sapiens | 33 | ALA4339196 | cell-based format | Scientific Literature | |
| 2. | ALA4339656 | Binding | Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor measured after 2 hrs by liquid scintillation counting analysis | Rattus norvegicus | 27 | ALA4339196 | assay format | Scientific Literature | |
| 3. | ALA4339657 | ADME | Extraction ratio in human liver microsomes at 1 uM measured up to 60 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 25 | ALA4339196 | microsome format | Scientific Literature | |
| 4. | ALA4339658 | ADME | Inhibition of CYP1A2 in human liver microsomes | Homo sapiens | 19 | ALA4339196 | microsome format | Scientific Literature | |
| 5. | ALA4339659 | ADME | Inhibition of CYP2C19 in human liver microsomes | Homo sapiens | 22 | ALA4339196 | microsome format | Scientific Literature | |
| 6. | ALA4339660 | ADME | Inhibition of CYP2C8 in human liver microsomes | Homo sapiens | 14 | ALA4339196 | microsome format | Scientific Literature | |
| 7. | ALA4339661 | ADME | Inhibition of CYP2C9 in human liver microsomes | Homo sapiens | 25 | ALA4339196 | microsome format | Scientific Literature | |
| 8. | ALA4339662 | ADME | Inhibition of CYP2D6 in human liver microsomes | Homo sapiens | 14 | ALA4339196 | microsome format | Scientific Literature | |
| 9. | ALA4339663 | ADME | Inhibition of CYP3A4 in human liver microsomes | Homo sapiens | 14 | ALA4339196 | microsome format | Scientific Literature | |
| 10. | ALA4339664 | ADME | Extraction ratio in rat liver microsomes at 1 uM measured up to 60 mins in presence of NADPH by LC/MS/MS analysis | Rattus norvegicus | 25 | ALA4339196 | microsome format | Scientific Literature | |
| 11. | ALA4339665 | Binding | Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysis | Homo sapiens | 30 | ALA4339196 | cell-based format | Scientific Literature | |
| 12. | ALA4339666 | ADME | Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral side in MDCK-MDR1 cells at 5 uM after 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 17 | ALA4339196 | cell-based format | Scientific Literature |
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