# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4414785 | B | Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mins by HTRF assay | Homo sapiens | 22 | ALA4414548 | single protein format | Scientific Literature | |
2. | ALA4414786 | B | Inhibition of TYK2 JH1 domain (unknown origin) | Homo sapiens | 10 | ALA4414548 | single protein format | Scientific Literature | |
3. | ALA4414787 | B | Inhibition of JAK1 JH1 domain (unknown origin) | Homo sapiens | 10 | ALA4414548 | single protein format | Scientific Literature | |
4. | ALA4414788 | B | Inhibition of JAK2 JH1 domain (unknown origin) | Homo sapiens | 10 | ALA4414548 | single protein format | Scientific Literature | |
5. | ALA4414789 | B | Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assay | Homo sapiens | 25 | ALA4414548 | assay format | Scientific Literature | |
6. | ALA4414790 | B | Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assay | Homo sapiens | 27 | ALA4414548 | assay format | Scientific Literature | |
7. | ALA4414791 | A | Inhibition of JAK1/JAK3 (unknown origin) in IL-2 stimulated cells by cell based assay | Homo sapiens | 8 | ALA4414548 | cell-based format | Scientific Literature | |
8. | ALA4414792 | A | Inhibition of JAK1/JAK2 (unknown origin) in GM-CSF stimulated cells by cell based assay | Homo sapiens | 8 | ALA4414548 | cell-based format | Scientific Literature | |
9. | ALA4414793 | B | Inhibition of TYK2 JH2 domain in human whole blood assessed as inhibition of IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by IFNalpha stimulation and measured after 15 mins by fluorescence assay | Homo sapiens | 20 | ALA4414548 | tissue-based format | Scientific Literature | |
10. | ALA4414797 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 10 mins | Homo sapiens | 9 | ALA4414548 | microsome format | Scientific Literature | |
11. | ALA4414798 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining after 10 mins | Rattus norvegicus | 9 | ALA4414548 | microsome format | Scientific Literature | |
12. | ALA4414799 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining after 10 mins | Mus musculus | 9 | ALA4414548 | microsome format | Scientific Literature | |
13. | ALA4414800 | B | Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by IFNalpha stimulation and measured after 15 mins by fluorescence assay | Mus musculus | 8 | ALA4414548 | tissue-based format | Scientific Literature |