# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4335958 | F | Induction of apoptosis in human A549 cells assessed as increase in caspase-3 activity at 15 uM measured after 24 hrs by Ac-DEVD-pNA substrate based assay relative to control | Homo sapiens | 2 | ALA4334452 | cell-based format | Scientific Literature | |
2. | ALA4335959 | F | Induction of mitochondrial membrane disruption in human A549 cells assessed as increase in cytochrome C level in cytoplasm at 15 uM measured after 24 hrs by immunofluorescence assay | Homo sapiens | 2 | ALA4334452 | cell-based format | Scientific Literature | |
3. | ALA4335960 | F | Induction of mitochondrial membrane potential loss in human A549 cells at 15 uM measured after 24 hrs by JC1 staining based fluorescence microscopic analysis | Homo sapiens | 2 | ALA4334452 | cell-based format | Scientific Literature | |
4. | ALA4335961 | A | Binding affinity to GLUT1 in human A549 cells assessed as drug uptake in mitochondria at 15 uM measured after 2 hrs using FITC-labelled compound by mito-tracker red/DAPI staining-based laser confocal microscopic analysis | Homo sapiens | 2 | ALA4334452 | mitochondrion format | Scientific Literature | |
5. | ALA4335962 | F | Induction of apoptosis in human A549 cells assessed as appearance of surface bubbling at 15 uM measured after 24 hrs by scanning electron microscopic analysis | Homo sapiens | 2 | ALA4334452 | cell-based format | Scientific Literature | |
6. | ALA4335963 | F | Induction of apoptosis in human A549 cells assessed as appearance of apoptotic bodies at 15 uM measured after 24 hrs by scanning electron microscopic analysis | Homo sapiens | 2 | ALA4334452 | cell-based format | Scientific Literature | |
7. | ALA4335964 | B | Binding affinity to GLUT1 in human A549 cells assessed as cytotoxicity by measuring increase in LDH release at 25 uM measured after 2 hrs | Homo sapiens | 2 | ALA4334452 | cell-based format | Scientific Literature | |
8. | ALA4335965 | A | Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 24 hrs by CCK8 assay | Homo sapiens | 5 | ALA4334452 | cell-based format | Scientific Literature | |
9. | ALA4335966 | B | Binding affinity to GLUT1 in human L02 cells assessed as cytotoxicity by measuring reduction in cell viability measured after 24 hrs by CCK8 assay | Homo sapiens | 3 | ALA4334452 | cell-based format | Scientific Literature | |
10. | ALA4335967 | B | Binding affinity to GLUT1 in human MDA-MB-231 cells assessed as cytotoxicity by measuring reduction in cell viability measured after 24 hrs by CCK8 assay | Homo sapiens | 3 | ALA4334452 | cell-based format | Scientific Literature | |
11. | ALA4335968 | B | Binding affinity to GLUT1 in human A549 cells assessed as cytotoxicity by measuring reduction in cell viability measured after 24 hrs by CCK8 assay | Homo sapiens | 5 | ALA4334452 | cell-based format | Scientific Literature | |
12. | ALA4335969 | B | Binding affinity to GLUT1 in human NCI-H460 cells assessed as cytotoxicity by measuring reduction in cell viability measured after 24 hrs by CCK8 assay | Homo sapiens | 3 | ALA4334452 | cell-based format | Scientific Literature | |
13. | ALA4335970 | B | Binding affinity to GLUT1 in human NCI-H1437 cells assessed as cytotoxicity by measuring reduction in cell viability measured after 24 hrs by CCK8 assay | Homo sapiens | 3 | ALA4334452 | cell-based format | Scientific Literature | |
14. | ALA4335971 | B | Binding affinity to GLUT1 in human HGC27 cells assessed as cytotoxicity by measuring reduction in cell viability measured after 24 hrs by CCK8 assay | Homo sapiens | 3 | ALA4334452 | cell-based format | Scientific Literature | |
15. | ALA4335972 | B | Binding affinity to GLUT1 in human PC3 cells assessed as cytotoxicity by measuring reduction in cell viability measured after 24 hrs by CCK8 assay | Homo sapiens | 3 | ALA4334452 | cell-based format | Scientific Literature | |
16. | ALA4335973 | B | Binding affinity to GLUT1 in human A549 cells assessed as cytotoxicity by measuring reduction in cell viability at 15 uM by trypan blue staining-based assay | Homo sapiens | 6 | ALA4334452 | cell-based format | Scientific Literature | |
17. | ALA4335975 | F | Induction of apoptosis in human A549 cells assessed as viable cells at 8 uM measured after 4 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 95.4%) | Homo sapiens | 2 | ALA4334452 | cell-based format | Scientific Literature | |
18. | ALA4335976 | F | Induction of apoptosis in human A549 cells assessed as early apoptotic cells at 8 uM measured after 4 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 0.39%) | Homo sapiens | 2 | ALA4334452 | cell-based format | Scientific Literature | |
19. | ALA4335977 | F | Induction of apoptosis in human A549 cells assessed as late apoptotic cells at 8 uM measured after 4 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 3.61%) | Homo sapiens | 2 | ALA4334452 | cell-based format | Scientific Literature | |
20. | ALA4335978 | F | Induction of apoptosis in human A549 cells assessed as necrotic cells at 8 uM measured after 4 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 0.51%) | Homo sapiens | 2 | ALA4334452 | cell-based format | Scientific Literature |