| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4388737 | A | Time dependent inhibition of CYP3A4 in human liver microsomes assessed as enzyme residual activity at 100 uM relative to control | Homo sapiens | 7 | microsome format | Scientific Literature | ||
| 2. | ALA4388738 | A | Inhibition of CYP1A2 (unknown origin) at 10 uM relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 3. | ALA4388739 | B | Induction of alkaline phosphatase activity in mouse ST-2 cells after 4 days by spectrophotometric method | Mus musculus | 37 | cell-based format | Scientific Literature | ||
| 4. | ALA4388740 | P | Solubility of the compound in pH 6.8 JP2 solution | 7 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA4388741 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 30 mins | Homo sapiens | 7 | microsome format | Scientific Literature | ||
| 6. | ALA4388742 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining after 30 mins | Rattus norvegicus | 7 | microsome format | Scientific Literature | ||
| 7. | ALA4388743 | A | Inhibition of CYP2C9 (unknown origin) at 10 uM relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 8. | ALA4388744 | A | Inhibition of CYP2C19 (unknown origin) at 10 uM relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 9. | ALA4388745 | A | Inhibition of CYP2D6 (unknown origin) at 10 uM relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 10. | ALA4388746 | A | Inhibition of CYP3A4 (unknown origin) at 10 uM relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 11. | ALA4388747 | A | Cmax in F344 rat at 30 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4388748 | A | AUC (0 to 8 hrs) in F344 rat at 30 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4388751 | F | Bone anabolic activity in ovariectomized F344 rat assessed as increase in areal bone mineral density in distal femur at 30 mg/kg/day, po administered for 5 weeks measured post-last dose by dual energy X-ray absorptiometry | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4388752 | F | Bone anabolic activity in ovariectomized F344 rat assessed as increase in areal bone mineral density in proximal femur at 30 mg/kg/day, po administered for 5 weeks measured post-last dose by dual energy X-ray absorptiometry | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4388753 | F | Bone anabolic activity in ovariectomized F344 rat assessed as increase in areal bone mineral density in total femur at 30 mg/kg/day, po administered for 5 weeks measured post-last dose by dual energy X-ray absorptiometry | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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