# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4341882 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 13 | ALA4340547 | microsome format | Scientific Literature | |
2. | ALA4341884 | B | Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced YO PRO dye uptake preincubated for 20 mins followed by YO PRO dye and BzATP addition measured after 30 mins by fluorescence assay | Homo sapiens | 20 | ALA4340547 | cell-based format | Scientific Literature | |
3. | ALA4341885 | B | Antagonist activity at P2X7R in LPS-stimulated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated for 30 mins followed by BzATP stimulation and measured after 30 mins by sandwich ELISA | Homo sapiens | 20 | ALA4340547 | assay format | Scientific Literature | |
4. | ALA4341886 | A | Intrinsic clearance in mouse liver microsomes | Mus musculus | 13 | ALA4340547 | microsome format | Scientific Literature | |
5. | ALA4341887 | A | Intrinsic clearance in rat liver microsomes | Rattus norvegicus | 13 | ALA4340547 | microsome format | Scientific Literature | |
6. | ALA4341888 | A | Apparent permeability across apical to basolateral side in MDCK cells expressing MDR | Canis lupus familiaris | 13 | ALA4340547 | cell-based format | Scientific Literature | |
7. | ALA4341889 | A | Efflux ratio of apparent permeability in MDCK cells expressing MDR | Canis lupus familiaris | 13 | ALA4340547 | cell-based format | Scientific Literature | |
8. | ALA4341890 | B | Antagonist activity at rat P2X7 receptor assessed as inhibition of BzATP-induced YO PRO dye uptake preincubated for 20 mins followed by YO PRO dye and BzATP addition measured after 30 mins by fluorescence assay | Rattus norvegicus | 7 | ALA4340547 | single protein format | Scientific Literature | |
9. | ALA4341891 | B | Antagonist activity at mouse P2X7 receptor assessed as inhibition of BzATP-induced YO PRO dye uptake preincubated for 20 mins followed by YO PRO dye and BzATP addition measured after 30 mins by fluorescence assay | Mus musculus | 7 | ALA4340547 | single protein format | Scientific Literature |