# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4313830 | Functional | Antitrypanosomal activity against Trypanosoma brucei bloodstream form assessed as parasite growth inhibition incubated for 72 hrs by resazurin dye based assay | Trypanosoma brucei | 39 | ALA4311972 | organism-based format | Scientific Literature | |
2. | ALA4313837 | ADME | Cytotoxicity against human THP1 cells by MTT assay | Homo sapiens | 37 | ALA4311972 | cell-based format | Scientific Literature | |
3. | ALA4313840 | Binding | Inhibition of human ERG at 10 uM incubated for 2 hrs by fluorescence polarization assay relative to control | Homo sapiens | 39 | ALA4311972 | single protein format | Scientific Literature | |
4. | ALA4313841 | ADME | Inhibition of human microsomal CYP1A2 expressed in baculovirus infected insect cells at 10 uM using luciferin-1A2 as substrate preincubated with enzyme/substrate mixture for 30 mins followed by further incubation with NADPH for 30 mins by CYP450 luciferase Glo assay relative to control | Homo sapiens | 39 | ALA4311972 | cell-based format | Scientific Literature | |
5. | ALA4313842 | ADME | Inhibition of human microsomal CYP2C9 expressed in baculovirus infected insect cells at 10 uM using luciferin-H as substrate preincubated with enzyme/substrate mixture for 30 mins followed by further incubation with NADPH for 30 mins by CYP450 luciferase Glo assay relative to control | Homo sapiens | 39 | ALA4311972 | cell-based format | Scientific Literature | |
6. | ALA4313843 | ADME | Inhibition of human microsomal CYP2C19 expressed in baculovirus infected insect cells at 10 uM using luciferin-H EGE as substrate preincubated with enzyme/substrate mixture for 30 mins followed by further incubation with NADPH for 30 mins by CYP450 luciferase Glo assay relative to control | Homo sapiens | 39 | ALA4311972 | cell-based format | Scientific Literature | |
7. | ALA4313844 | ADME | Inhibition of human microsomal CYP2D6 expressed in baculovirus infected insect cells at 10 uM using luciferin-ME as substrate preincubated with enzyme/substrate mixture for 30 mins followed by further incubation with NADPH for 30 mins by CYP450 luciferase Glo assay relative to control | Homo sapiens | 39 | ALA4311972 | cell-based format | Scientific Literature | |
8. | ALA4313845 | ADME | Inhibition of human microsomal CYP3A4 expressed in baculovirus infected insect cells at 10 uM using luciferin-IPA as substrate preincubated with enzyme/substrate mixture for 30 mins followed by further incubation with NADPH for 30 mins by CYP450 luciferase Glo assay relative to control | Homo sapiens | 39 | ALA4311972 | cell-based format | Scientific Literature | |
9. | ALA4313846 | ADME | Cytotoxicity against human A549 cells assessed as cell growth at 10 mM incubated for 48 hrs by Celltiter-Glo luminescence assay relative to control | Homo sapiens | 39 | ALA4311972 | cell-based format | Scientific Literature | |
10. | ALA4313847 | Toxicity | Mitochondrial toxicity in human 786-0 cells at 10 uM incubated with compound for 6 hrs followed by incubation with MitoTracker Red chloromethyl-X-rosamine dye for 45 mins by imaging analysis | Homo sapiens | 39 | ALA4311972 | cell-based format | Scientific Literature |