# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4390077 | B | Positive allosteric modulation activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current by measuring maximum efficacy of acetylcholine at 10 uM at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method (Rvb = 339%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA4390078 | B | Positive allosteric modulation activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method | Homo sapiens | 32 | cell-based format | Scientific Literature | ||
3. | ALA4390079 | B | Positive allosteric modulation activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current at 10 uM at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method relative to control | Homo sapiens | 32 | cell-based format | Scientific Literature | ||
4. | ALA4390080 | B | Positive allosteric modulation activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current at 0.1 uM to 30 uM at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA4390081 | B | Induction of desensitization of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as acetylcholine-induced channel desensitization time constant at 10 uM at -90 mV holding potential by two-electrode voltage clamp method (Rvb = 6.37 +/- 2.56 No_unit) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
6. | ALA4390082 | B | Positive allosteric modulation activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current by measuring acetylcholine EC50 at 10 uM at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method (Rvb = 231.8 +/- 2 uM) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
7. | ALA4390085 | B | Positive allosteric modulation activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current by measuring maximum efficacy of acetylcholine at 10 uM at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA4390086 | B | Agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in channel current at -90 mV holding potential by two-electrode voltage clamp method | Homo sapiens | 32 | cell-based format | Scientific Literature | ||
9. | ALA4390087 | B | Positive allosteric modulation activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current at 10 uM at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
10. | ALA4390088 | B | Positive allosteric modulation activity at rat alpha4beta2 nAChR expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current at 10 uM at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
11. | ALA4390089 | B | Positive allosteric modulation activity at human 5-HT3A receptor expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current at 10 uM at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |