#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4411225	Binding	Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate addition and measured after 40 mins by HTRF assay	Homo sapiens	27	ALA4406925	cell-based format	Scientific Literature
2.	ALA4411226	Physicochemical	Kinetic solubility of the compound in water		5	ALA4406925	small-molecule physicochemical format	Scientific Literature
3.	ALA4411227	ADME	Stability in rat Hepatocyte assessed per million cells	Rattus norvegicus	5	ALA4406925	cell-based format	Scientific Literature
4.	ALA4411228	ADME	Apparent permeability in MDCK-MDR1 cells expressing p-gp	Canis lupus familiaris	5	ALA4406925	cell-based format	Scientific Literature
5.	ALA4411229	ADME	Efflux ratio of apparent permeability across apical side over basolateral side to basolateral side over apical side in MDCK-MDR1 cells expressing P-glycoprotein	Canis lupus familiaris	5	ALA4406925	cell-based format	Scientific Literature
6.	ALA4411230	ADME	Oral bioavailability in rat at 10 mg/kg	Rattus norvegicus	5	ALA4406925	organism-based format	Scientific Literature
7.	ALA4411231	ADME	Half life in rat at 1 mg/kg, iv	Rattus norvegicus	5	ALA4406925	organism-based format	Scientific Literature
8.	ALA4411232	ADME	Clearance in rat 1 mg/kg, iv or 10 mg/kg, po	Rattus norvegicus	5	ALA4406925	organism-based format	Scientific Literature
9.	ALA4411233	ADME	Fraction unbound in rat plasma by equlibrium dialysis method	Rattus norvegicus	5	ALA4406925	cell-free format	Scientific Literature
10.	ALA4411234	ADME	Fraction unbound in rat brain	Rattus norvegicus	5	ALA4406925	tissue-based format	Scientific Literature
11.	ALA4411241	ADME	Unbound brain to plasma concentration ratio in rat at 100 mg/kg, po measured after 4 hrs	Rattus norvegicus	5	ALA4406925	organism-based format	Scientific Literature
12.	ALA4411242	ADME	Ratio of fraction unbound in rat brain to inhibition of human M-COMT expressed in HEK293 cells		5	ALA4406925	cell-based format	Scientific Literature
13.	ALA4411244	Binding	Inhibition of recombinant human C-terminal His6-tagged S-COMT expressed in 293-6E cells using 7,8-dihydroxy-4-methylcoumarin as substrate and SAM as cofactor incubated for 1 hr by MTase Glo methyltransferase assay	Homo sapiens	5	ALA4406925	cell-based format	Scientific Literature
14.	ALA4411246	ADME	Drug concentration in rat plasma at 100 mg/kg, po measured after 4 hrs	Rattus norvegicus	5	ALA4406925	organism-based format	Scientific Literature
15.	ALA4411247	ADME	Drug concentration in rat brain at 100 mg/kg, po measured after 4 hrs	Rattus norvegicus	5	ALA4406925	organism-based format	Scientific Literature
16.	ALA4411248	ADME	Drug concentration in rat cerebrospinal fluid at 100 mg/kg, po measured after 4 hrs	Rattus norvegicus	5	ALA4406925	organism-based format	Scientific Literature
17.	ALA4411249	ADME	Ratio of drug level in brain to plasma in rat at 100 mg/kg, po measured after 4 hrs	Rattus norvegicus	5	ALA4406925	organism-based format	Scientific Literature
18.	ALA4411250	ADME	Fraction unbound in rat plasma at 100 mg/kg, po measured after 4 hrs	Rattus norvegicus	5	ALA4406925	organism-based format	Scientific Literature
19.	ALA4411251	ADME	Fraction unbound in rat brain at 100 mg/kg, po measured after 4 hrs	Rattus norvegicus	5	ALA4406925	organism-based format	Scientific Literature
20.	ALA4411252	Functional	In vivo inhibition of COMT in rat assessed as change in HVA level at 100 mg/kg, po measured after 4 hrs by LC-MS analysis relative to control	Rattus norvegicus	5	ALA4406925	organism-based format	Scientific Literature