# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4429649 | Binding | Displacement of [125I]-orexin A from human OX2 receptor expressed in CHO cell membranes at 10 uM after 90 mins by scintillation counting | Homo sapiens | 11 | ALA4428072 | cell-based format | Scientific Literature | |
2. | ALA4429655 | Binding | Displacement of [125I]-orexin A from human OX1 receptor expressed in CHO cell membranes after 90 mins by scintillation counting | Homo sapiens | 12 | ALA4428072 | cell-based format | Scientific Literature | |
3. | ALA4429656 | Binding | Displacement of [125I]-orexin A from human OX2 receptor expressed in CHO cell membranes after 90 mins by scintillation counting | Homo sapiens | 12 | ALA4428072 | cell-based format | Scientific Literature | |
4. | ALA4429658 | Functional | Antagonist activity at human OX1 receptor expressed in CHO cell membranes assessed as inhibition of orexin A-induced Ca2+ elevation after 30 mins in presence of orexin A by FLIPR calcium 4 assay | Homo sapiens | 7 | ALA4428072 | cell-based format | Scientific Literature | |
5. | ALA4429659 | Functional | Antagonist activity at human OX2 receptor expressed in CHO cell membranes assessed as inhibition of orexin A-induced Ca2+ elevation after 30 mins in presence of orexin A by FLIPR calcium 4 assay | Homo sapiens | 7 | ALA4428072 | cell-based format | Scientific Literature | |
6. | ALA4429660 | Binding | Ratio of Ki for human OX1 receptor expressed in CHO cell membranes assessed as inhibition of orexin A-induced Ca2+ elevation to Ki for human OX1 receptor expressed in CHO cells by [125I]-orexin A displacement assay | Homo sapiens | 7 | ALA4428072 | cell-based format | Scientific Literature | |
7. | ALA4429665 | Functional | Agonist activity at human OX1 receptor expressed in CHO cells assessed as induction of Ca2+ elevation at 5 uM after 30 mins by FLIPR calcium 4 assay relative to orexin-A | Homo sapiens | 11 | ALA4428072 | cell-based format | Scientific Literature | |
8. | ALA4429666 | Functional | Agonist activity at human OX2 receptor expressed in CHO cells assessed as induction of Ca2+ elevation at 5 uM after 30 mins by FLIPR calcium 4 assay relative to orexin-A | Homo sapiens | 11 | ALA4428072 | cell-based format | Scientific Literature | |
9. | ALA4429667 | Functional | Antagonist activity at human OX1 receptor expressed in CHO cells assessed as inhibition of orexin A-induced Ca2+ elevation at 5 uM after 30 mins by FLIPR calcium 4 assay | Homo sapiens | 7 | ALA4428072 | cell-based format | Scientific Literature | |
10. | ALA4429668 | Functional | Antagonist activity at human OX2 receptor expressed in CHO cells assessed as inhibition of orexin A-induced Ca2+ elevation at 5 uM after 30 mins by FLIPR calcium 4 assay | Homo sapiens | 7 | ALA4428072 | cell-based format | Scientific Literature | |
11. | ALA4429669 | Binding | Displacement of [125I]-orexin A from human OX1 receptor expressed in CHO cell membranes at 10 uM after 90 mins by scintillation counting | Homo sapiens | 11 | ALA4428072 | cell-based format | Scientific Literature | |
12. | ALA4429672 | Binding | Ratio of Ki for human OX1 receptor expressed in CHO cells to Ki for human OX2 receptor expressed in CHO cells by Ca2+ elevation based assay | Homo sapiens | 2 | ALA4428072 | cell-based format | Scientific Literature |