# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4367522 | B | Activation of BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells assessed as induction of IL2-stimulated cell proliferation by measuring increase in CD3+ cells preincubated for 3 days followed by 11 days incubation post compound washout and subsequent IL2 stimulation for every 3 days measured after 14 days by flow cytometry | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
2. | ALA4367524 | B | Activation of BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells assessed as induction of IL2-stimulated cell proliferation by measuring increase in CD3+ cells at 10 uM preincubated for 3 days followed by 11 days incubation post compound washout and subsequent IL2 stimulation for every 3 days measured after 14 days by flow cytometry relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
3. | ALA4367525 | B | Activation of BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells assessed as induction of IL2-stimulated cell proliferation by measuring increase in CD3+ cells up to 100 uM preincubated for 3 days followed by 11 days incubation post compound washout and subsequent IL2 stimulation for every 3 days measured after 14 days by flow cytometry | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
4. | ALA4367526 | A | Drug uptake in human PBMC assessed as parent compound remaining at 10 uM measured after 6 hrs by UPLC-MS analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
5. | ALA4367527 | A | Drug uptake in human PBMC assessed as parent compound remaining at 10 uM measured after 24 hrs by UPLC-MS analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4367528 | U | Drug uptake in T cell media assessed as parent compound remaining at 10 uM measured after 48 hrs by UPLC-MS analysis | 2 | assay format | Scientific Literature | |||
7. | ALA4367529 | B | Activation of BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells assessed as induction of IL2-stimulated IFNgamma production measured after 48 hrs by ELISA | Homo sapiens | 11 | assay format | Scientific Literature | ||
8. | ALA4367534 | B | Displacement of GDP-BODIPY from C-terminal 6His-tagged BTN3A1 B30.2 domain (unknown origin) expressed in Escherichia coli BL21 (DE) measured after 60 mins by fluorescence polarization assay | Homo sapiens | 11 | assay format | Scientific Literature |