| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4481328 | B | Inhibition of full length His-tagged human DDX3X expressed in Escherichia coli assessed as reduction in DDX3X helicase activity using FAM-labeled double stranded RNA as substrate after 40 mins by FRET assay relative to control | Homo sapiens | 21 | assay format | Scientific Literature | ||
| 2. | ALA4481332 | A | Inhibition of human DDX3X ATPase activity using DDX3 as substrate by ADP-Glo kinase assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 3. | ALA4481333 | A | Inhibition of human DDX1 helicase activity | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 4. | ALA4481334 | A | Cytotoxicity against human HuH7 cells after 3 days by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 5. | ALA4481337 | F | Antiviral activity against West Nile virus infected in human HuH7 cells incubated for 4 days by crystal violet staining based plaque reduction assay | West Nile virus | 10 | organism-based format | Scientific Literature | ||
| 6. | ALA4481340 | A | Apparent permeability of the compound by PAMPA | 7 | assay format | Scientific Literature | |||
| 7. | ALA4481341 | P | Aqueous solubility of the compound at 1 mg after 24 to 36 hrs by LC-MS/MS analysis | 7 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA4481342 | A | Metabolic stability in human liver microsomes at 50 uM after 60 mins in presence of NADPH-generating system by LC-UV-MS analysis | Homo sapiens | 7 | microsome format | Scientific Literature | ||
| 9. | ALA4616145 | F | Antiviral activity against Dengue virus serotype 2 New Guinea C infected at 50 TCID50 in human HuH7 cells assessed as inhibition of viral replication and 72 hrs later re-infected pre-seeded HuH7 cells with viral supernatant collected from previous infected and measured after 72 hrs by immunodetection assay | dengue virus type 2 | 21 | organism-based format | Scientific Literature | ||
| 10. | ALA4616148 | B | Inhibition of recombinant full length human His-tagged DDX3X expressed in Escherichia coli using dsRNA as substrate measured after 40 mins in presence of ATP by FRET assay | Homo sapiens | 24 | assay format | Scientific Literature | ||
| 11. | ALA4687212 | F | Antiviral activity against HIV-1 NL4-3 infected in human TZM-bl cells infected with supernatants from virus-infected human H9 cells treated with compound for 72 hrs assessed as reduction in luciferase expression measured after 48 hrs by luciferase reporter gene assay based BiCycle assay | Human immunodeficiency virus 1 | 12 | organism-based format | Scientific Literature | ||
| 12. | ALA4687213 | B | Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay | Homo sapiens | 26 | single protein format | Scientific Literature | ||
| 13. | ALA4687222 | A | Apparent permeability of compound incubated for 5 hrs by PAMPA assay | 9 | assay format | Scientific Literature | |||
| 14. | ALA4687223 | P | Aqueous solubility of compound at 1 mg incubated for 24 hrs by LC-MS/MS analysis | 9 | small-molecule physicochemical format | Scientific Literature | |||
| 15. | ALA4687224 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining measured after 60 mins by LC-UV-MS analysis | Homo sapiens | 9 | microsome format | Scientific Literature | ||
| 16. | ALA5216453 | B | Inhibition of recombinant DDX3X (unknown origin) helicase activity using dsRNA as substrate incubated for 40 mins by FRET assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 17. | ALA5216459 | F | Antiviral activity against HIV-1 NL4-3 infected in PBMC (unknown origin) assessed as reduction in viral replication | Human immunodeficiency virus 1 | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5216460 | T | Cytotoxicity against PBMC (unknown origin) assessed as reduction in cell viability | Not specified | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5216462 | T | Selectivity index, ratio of CC50 for hepatoma cells (unknown origin) to EC50 for HCV-1 infected in hepatoma cells (unknown origin) | 2 | cell-based format | Scientific Literature | |||
| 20. | ALA5216466 | F | Antiviral activity against HCV-1 infected in human LucUbiNeo-ET cells assessed as reduction in viral replication incubated for 2 days by luminometry | Hepacivirus hominis | 2 | organism-based format | Scientific Literature |
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