# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4417447 | ADME | Effect on total IRbeta expression in high fat diet-induced obese C57BL/6J mouse skeletal muscle at 100 to 300 mg/kg administered via gavage for 2 weeks and measured after 6 hrs post dose by Western blot analysis | Mus musculus | 1 | ALA4414673 | organism-based format | Scientific Literature | |
2. | ALA4417448 | Toxicity | Toxicity in high fat diet-induced C57BL/6J mouse assessed as upregulation of total AKT expression in adipose tissue at 300 mg/kg administered via gavage for 2 weeks and measured after 6 hrs post dose by Western blot analysis | Mus musculus | 1 | ALA4414673 | organism-based format | Scientific Literature | |
3. | ALA4417449 | Functional | Effect on insulin signalling in high fat diet-induced obese C57BL/6J mouse assessed as effect on AKT phosphorylation at threonine 308 residue expression in adipose tissue at 100 to 300 mg/kg administered via gavage for 2 weeks and measured after 6 hrs post dose by Western blot analysis | Mus musculus | 1 | ALA4414673 | organism-based format | Scientific Literature | |
4. | ALA4417450 | Functional | Effect on insulin signalling in high fat diet-induced obese C57BL/6J mouse assessed as increase in PI3K-P85 expression in skeletal muscle at 100 mg/kg administered via gavage for 2 weeks and measured after 6 hrs post dose by Western blot analysis | Mus musculus | 1 | ALA4414673 | organism-based format | Scientific Literature | |
5. | ALA4417451 | Functional | Effect on insulin signalling in high fat diet-induced obese C57BL/6J mouse assessed as increase in AKT phosphorylation at serine 273 residue in skeletal muscle at 100 to 300 mg/kg administered via gavage for 2 weeks and measured after 6 hrs post dose by Western blot analysis | Mus musculus | 1 | ALA4414673 | organism-based format | Scientific Literature | |
6. | ALA4417452 | Functional | Effect on insulin signalling in high fat diet-induced obese C57BL/6J mouse assessed as increase in IR-beta phosphorylation at tyrosine 1150 residue at 100 to 300 mg/kg administered via gavage for 2 weeks and measured after 6 hrs post dose by Western blot analysis | Mus musculus | 1 | ALA4414673 | organism-based format | Scientific Literature | |
7. | ALA4417453 | Functional | Hypoglycemic activity in high fat diet-induced obese C57BL/6J mouse assessed as increase in C-peptide level at 100 to 300 mg/kg administered via gavage for 2 weeks and measured after 6 hrs post dose | Mus musculus | 1 | ALA4414673 | organism-based format | Scientific Literature | |
8. | ALA4417454 | Functional | Hypoglycemic activity in high fat diet-induced obese C57BL/6J mouse assessed as increase in insulin level at 300 mg/kg administered via gavage for 2 weeks and measured after 6 hrs post dose | Mus musculus | 1 | ALA4414673 | organism-based format | Scientific Literature | |
9. | ALA4417455 | Functional | Hypoglycemic activity in high fat diet-induced obese C57BL/6J mouse assessed as reduction in blood glucose level at 100 to 300 mg/kg administered via gavage for 2 weeks and measured after 6 hrs post dose | Mus musculus | 1 | ALA4414673 | organism-based format | Scientific Literature | |
10. | ALA4417457 | Functional | Activation of insulin signalling in palmitate-induced insulin resistant mouse C2C12 cells assessed as increase in glycogen level at 10 ug/ml | Mus musculus | 1 | ALA4414673 | cell-based format | Scientific Literature | |
11. | ALA4417458 | Toxicity | Toxicity in high fat diet-induced obese C57BL/6J mouse assessed as effect on body weight at 100 to 300 mg/kg administered via gavage for 2 weeks and measured after 6 hrs post dose | Mus musculus | 1 | ALA4414673 | organism-based format | Scientific Literature | |
12. | ALA4417459 | Binding | Activation of insulin signalling in palmitate-induced insulin resistant mouse C2C12 cells assessed as upregulation of AKT phosphorylation at threonine 308 and Ser273 residue at 10 ug/ml by Western blot analysis | Mus musculus | 1 | ALA4414673 | cell-based format | Scientific Literature | |
13. | ALA4417460 | Functional | Effect on insulin signalling in high fat diet-induced C57BL/6J mouse assessed as AKT phosphorylation at Ser 273 residue in liver at 100 to 300 mg/kg administered via gavage for 2 weeks and measured after 6 hrs post dose by Western blot analysis | Mus musculus | 1 | ALA4414673 | organism-based format | Scientific Literature | |
14. | ALA4417461 | Functional | Effect on insulin signalling in high fat diet-induced obese C57BL/6J mouse assessed as effect on AKT phosphorylation at threonine 308 residue expression in liver at 100 to 300 mg/kg administered via gavage for 2 weeks and measured after 6 hrs post dose by Western blot analysis | Mus musculus | 1 | ALA4414673 | organism-based format | Scientific Literature | |
15. | ALA4417462 | Functional | Effect on insulin signalling in high fat diet-induced C57BL/6J mouse assessed as AKT phosphorylation at Ser 273 residue in adipose tissue at 100 to 300 mg/kg administered via gavage for 2 weeks and measured after 6 hrs post dose by Western blot analysis | Mus musculus | 1 | ALA4414673 | organism-based format | Scientific Literature | |
16. | ALA4417463 | Binding | Activation of insulin signalling in palmitate-induced insulin resistant mouse C2C12 cells assessed as increase GSK-3 alpha/beta phosphorylation at 10 ug/ml by Western blot analysis | Mus musculus | 1 | ALA4414673 | cell-based format | Scientific Literature |