# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4324119 | Binding | Inhibition of human recombinant GST-tagged wild type EGFR expressed in baculovirus expression system assessed as decrease in phosphorylation of ULight-poly-GT using ULight-poly-GT as substrate incubated for 90 mins in presence of ATP by TR-FRET LANCE assay | Homo sapiens | 6 | ALA4321840 | assay format | Scientific Literature | |
2. | ALA4324120 | Binding | Inhibition of GST-fusion tagged EGFR del19/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as decrease in phosphorylation of ULight-poly-GT using poly-GT as substrate in presence of ATP | Homo sapiens | 6 | ALA4321840 | cell-based format | Scientific Literature | |
3. | ALA4324121 | Binding | Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as decrease in phosphorylation of ULight-poly-GT using poly-GT as substrate in presence of ATP | Homo sapiens | 6 | ALA4321840 | cell-based format | Scientific Literature | |
4. | ALA4324122 | Binding | Inhibition of phosphorylated EGFR del19/T790M/C797S triple mutant (unknown origin) expressed in mouse BaF3 cells incubated for 4 hrs by Alphascreen assay | Homo sapiens | 12 | ALA4321840 | cell-based format | Scientific Literature | |
5. | ALA4324123 | Binding | Inhibition of EGFR del19/T790M/C797S triple mutant in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay | Mus musculus | 12 | ALA4321840 | cell-based format | Scientific Literature | |
6. | ALA4324124 | Binding | Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay | Mus musculus | 12 | ALA4321840 | cell-based format | Scientific Literature | |
7. | ALA4324125 | ADME | Cytotoxicity against mouse BAF3 cells incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay | Mus musculus | 12 | ALA4321840 | cell-based format | Scientific Literature |