# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4479462 | Binding | Inhibition of EZH2 histone methyltransferase activity of EZH2/EED/SUZ12 protein complex (unknown origin) using histone H3 peptide as substrate (21 to 44 residues) in presence of [3H]-S-adenosylmethionine after 2 hrs by scintillation proximity assay | Homo sapiens | 54 | ALA4477241 | single protein format | Scientific Literature | |
2. | ALA4479463 | Binding | Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as substrate (21 to 44 residues) in presence of [3H]-S-adenosylmethionine after 2 hrs by scintillation proximity assay | Homo sapiens | 54 | ALA4477241 | single protein format | Scientific Literature | |
3. | ALA5111868 | Binding | Binding affinity to recombinant PRC2 complex (unknown origin) assessed as dissociation rate constant incubated for 90 seconds by surface plasmon resonance assay | Homo sapiens | 17 | ALA5108052 | assay format | Scientific Literature | |
4. | ALA5111869 | Binding | Binding affinity to recombinant PRC2 complex (unknown origin) assessed as association rate constant incubated for 90 seconds by surface plasmon resonance assay | Homo sapiens | 17 | ALA5108052 | assay format | Scientific Literature | |
5. | ALA5111870 | Binding | Binding affinity to recombinant PRC2 complex (unknown origin) incubated for 90 seconds by surface plasmon resonance assay | Homo sapiens | 17 | ALA5108052 | assay format | Scientific Literature | |
6. | ALA5111871 | Binding | Inhibition of EZH2 (unknown origin) | Homo sapiens | 4 | ALA5108052 | single protein format | Scientific Literature | |
7. | ALA5111872 | Functional | Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 31 | ALA5108052 | cell-based format | Scientific Literature | |
8. | ALA5111873 | Functional | Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 31 | ALA5108052 | cell-based format | Scientific Literature | |
9. | ALA5111874 | Functional | Antiproliferative activity against human SU-DHL-10 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 31 | ALA5108052 | cell-based format | Scientific Literature | |
10. | ALA5111875 | Functional | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 31 | ALA5108052 | cell-based format | Scientific Literature | |
11. | ALA5111876 | Functional | Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 31 | ALA5108052 | cell-based format | Scientific Literature | |
12. | ALA5111917 | Functional | Synergistic antiproliferative activity against human HL-60 cells assessed as combination index in presence of SAHA incubated for 72 hrs by CCK-8 assay | Homo sapiens | 3 | ALA5108052 | cell-based format | Scientific Literature | |
13. | ALA5111918 | Functional | Synergistic antiproliferative activity against human MV4-11 cells assessed as combination index in presence of SAHA incubated for 72 hrs by CCK-8 assay | Homo sapiens | 3 | ALA5108052 | cell-based format | Scientific Literature | |
14. | ALA5111919 | Functional | Synergistic antiproliferative activity against human SU-DHL-10 cells assessed as combination index in presence of SAHA incubated for 72 hrs by CCK-8 assay | Homo sapiens | 3 | ALA5108052 | cell-based format | Scientific Literature | |
15. | ALA5111920 | Functional | Synergistic antiproliferative activity against human MDA-MB-231 cells assessed as combination index in presence of SAHA incubated for 72 hrs by CCK-8 assay | Homo sapiens | 3 | ALA5108052 | cell-based format | Scientific Literature | |
16. | ALA5111921 | Functional | Synergistic antiproliferative activity against human HCT-116 cells assessed as combination index in presence of SAHA incubated for 72 hrs by CCK-8 assay | Homo sapiens | 3 | ALA5108052 | cell-based format | Scientific Literature | |
17. | ALA5231258 | Binding | Inhibition of EZH2 methyltransferase activity (unknown origin) assessed `transfer of [3H]methyl group from SAM to substrate by biochemical assay | Homo sapiens | 2 | ALA5230109 | single protein format | Scientific Literature | |
18. | ALA5231259 | Binding | Inhibition of EZH1 methyltransferase activity (unknown origin) assessed `transfer of [3H]methyl group from SAM to substrate by biochemical assay | Homo sapiens | 1 | ALA5230109 | single protein format | Scientific Literature | |
19. | ALA5238024 | Binding | Inhibition of EZH2 (unknown origin) | Homo sapiens | 3 | ALA5236580 | single protein format | Scientific Literature |