# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4345354 | Binding | Inhibition of human topo2alpha incubated for 30 mins by SYBR safe DNA stain based decatenation assay | Homo sapiens | 19 | ALA4342496 | single protein format | Scientific Literature | |
2. | ALA4345356 | Functional | Antiproliferative activity against human DU145 cells by MTT assay | Homo sapiens | 19 | ALA4342496 | cell-based format | Scientific Literature | |
3. | ALA4345357 | Functional | Antiproliferative activity against human HeLa cells by MTT assay | Homo sapiens | 19 | ALA4342496 | cell-based format | Scientific Literature | |
4. | ALA4345358 | Functional | Antiproliferative activity against human A549 cells by MTT assay | Homo sapiens | 19 | ALA4342496 | cell-based format | Scientific Literature | |
5. | ALA4345359 | Physicochemical | Kinetic solubility in neutral buffer | 7 | ALA4342496 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4345360 | Binding | Poison activity at human topo2alpha assessed as induction of accumulation of topo-2/DNA cleavage complex formation at 200 uM using pBR233 plasmid incubated for 6 mins by by SYBR safe DNA stain based cleavage complex formation assay | Homo sapiens | 3 | ALA4342496 | single protein format | Scientific Literature | |
7. | ALA4345361 | ADME | Half life in mouse plasma | Mus musculus | 6 | ALA4342496 | cell-free format | Scientific Literature | |
8. | ALA4345362 | ADME | Half life in mouse liver microsomes | Mus musculus | 6 | ALA4342496 | microsome format | Scientific Literature | |
9. | ALA4345363 | Physicochemical | Thermodynamic solubility in PBS | 1 | ALA4342496 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4345364 | ADME | Protein binding in mouse plasma | Mus musculus | 1 | ALA4342496 | cell-free format | Scientific Literature | |
11. | ALA4345365 | ADME | Protein binding in human plasma | Homo sapiens | 1 | ALA4342496 | cell-free format | Scientific Literature | |
12. | ALA4345366 | ADME | Cmax in mouse at 3 mg/kg, iv | Mus musculus | 1 | ALA4342496 | organism-based format | Scientific Literature | |
13. | ALA4345367 | ADME | Tmax in mouse at 3 mg/kg, iv | Mus musculus | 1 | ALA4342496 | organism-based format | Scientific Literature | |
14. | ALA4345368 | ADME | AUC in mouse at 3 mg/kg, iv | Mus musculus | 1 | ALA4342496 | organism-based format | Scientific Literature | |
15. | ALA4345369 | ADME | Elimination half life in mouse at 3 mg/kg, iv | Mus musculus | 1 | ALA4342496 | organism-based format | Scientific Literature | |
16. | ALA4345370 | ADME | Volume of distribution in mouse at 3 mg/kg, iv | Mus musculus | 1 | ALA4342496 | organism-based format | Scientific Literature | |
17. | ALA4345371 | ADME | Clearance in mouse at 3 mg/kg, iv | Mus musculus | 1 | ALA4342496 | organism-based format | Scientific Literature | |
18. | ALA4345372 | ADME | Cmax in mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4342496 | organism-based format | Scientific Literature | |
19. | ALA4345373 | ADME | Tmax in mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4342496 | organism-based format | Scientific Literature | |
20. | ALA4345374 | ADME | AUC in mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4342496 | organism-based format | Scientific Literature |