# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4361683 | Binding | Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex membrane | Rattus norvegicus | 17 | ALA4359847 | cell membrane format | Scientific Literature | |
2. | ALA4361684 | Binding | Displacement of [125I]alpha-bungarotoxin from alpha7nAChR in rat hippocampus membrane | Rattus norvegicus | 17 | ALA4359847 | cell membrane format | Scientific Literature | |
3. | ALA4361685 | Binding | Selectivity index, ratio of Ki for alpha7 nAChR in rat hippocampus membrane to Ki for alpha4beta2 nAChR in rat cerebral cortex membrane | Rattus norvegicus | 16 | ALA4359847 | cell membrane format | Scientific Literature | |
4. | ALA4361686 | Binding | Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK243 cell membrane | Homo sapiens | 17 | ALA4359847 | cell-based format | Scientific Literature | |
5. | ALA4361687 | Binding | Selectivity index, ratio of Ki for human alpha3beta4 nAChR in HEK243 cell membrane to Ki for alpha4beta2 nAChR in rat cerebral cortex membrane | 16 | ALA4359847 | cell-based format | Scientific Literature | ||
6. | ALA4361688 | Binding | Agonist activity at human alpha4beta2 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70 mV holding potential by patch clamp assay relative to acetylcholine | Homo sapiens | 3 | ALA4359847 | cell-based format | Scientific Literature | |
7. | ALA4361689 | Binding | Agonist activity at human alpha4beta2 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70 mV holding potential by patch clamp assay | Homo sapiens | 3 | ALA4359847 | cell-based format | Scientific Literature | |
8. | ALA4361690 | Binding | Agonist activity at human alpha3beta4 nAChR expressed in GH4C1 cells assessed as increase in inward channel current at >1 uM measured after 3 to 4 days at -70 mV holding potential by patch clamp assay | Homo sapiens | 2 | ALA4359847 | cell-based format | Scientific Literature | |
9. | ALA4361691 | Binding | Agonist activity at human alpha3beta4 nAChR expressed in GH4C1 cells assessed as increase in inward channel current measured after 3 to 4 days at -70 mV holding potential by patch clamp assay | Homo sapiens | 2 | ALA4359847 | cell-based format | Scientific Literature |