# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4338992 | Functional | Antiviral activity in HBV infected in human HepG2.2.15 cells assessed as reduction in viral replication incubated for 5 days by qPCR analysis | Hepatitis B virus | 2 | ALA4334551 | organism-based format | Scientific Literature | |
2. | ALA4338994 | Functional | Antiviral activity in HBV infected in human HepAD38 cells assessed as reduction in viral replication incubated for 65 hrs by RT-PCR analysis | Hepatitis B virus | 12 | ALA4334551 | organism-based format | Scientific Literature | |
3. | ALA4338995 | ADME | Cytotoxicity against human HepAD38 cells assessed as reduction in cell viability incubated for 65 hrs by EZ-Cytox cell viability assay | Homo sapiens | 12 | ALA4334551 | cell-based format | Scientific Literature | |
4. | ALA4434278 | ADME | Half life in human at 200 mg | Homo sapiens | 1 | ALA4433248 | assay format | Scientific Literature | |
5. | ALA4434279 | Functional | Antiviral activity against Hepatitis B virus infected in naive HBeAg positive patients assessed as log10 reduction in HBV DNA at 600 mg bid | Hepatitis B virus | 1 | ALA4433248 | organism-based format | Scientific Literature | |
6. | ALA4434280 | Binding | Binding affinity to capsid protein in Hepatitis B virus infected in human HepG2.2.15 cells assessed as inhibition of HBV DNA replication incubated for 3 days followed by replacement of fresh medium containing compound and measured after 3 days by chemiluminescent assay | Hepatitis B virus | 21 | ALA4433248 | cell-based format | Scientific Literature | |
7. | ALA4434281 | ADME | Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 3 days followed by replacement of fresh medium containing compound and measured after 3 days by cell titer glo-based luminescence assay | Homo sapiens | 21 | ALA4433248 | cell-based format | Scientific Literature | |
8. | ALA4434296 | Functional | Ratio of EC50 for antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells in presence of 40% normal human serum to EC50 for antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells in absence of 40% normal human serum | Hepatitis B virus | 3 | ALA4433248 | organism-based format | Scientific Literature | |
9. | ALA4434297 | Physicochemical | Lipophilicity, log P of the compound | 3 | ALA4433248 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4434305 | ADME | Ratio of drug concentration in liver to plasma of CD1 mouse | Mus musculus | 3 | ALA4433248 | cell-free format | Scientific Literature | |
11. | ALA4620093 | Functional | Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells by solid phase radioimmunoassay | Hepatitis B virus | 8 | ALA4619714 | organism-based format | Scientific Literature | |
12. | ALA4620094 | ADME | Cytotoxicity against human HepG2.2.15 cells | Homo sapiens | 8 | ALA4619714 | cell-based format | Scientific Literature | |
13. | ALA4620095 | Toxicity | Selectivity index, ratio of CC50 for human HepG2.2.15 cells to IC50 for Hepatitis B virus | 8 | ALA4619714 | assay format | Scientific Literature | ||
14. | ALA4620096 | Physicochemical | Solubility of compound at pH 2 by HPLC-UV analysis | 1 | ALA4619714 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA4620097 | ADME | Half life in ICR mouse at 50 mg/kg, po | Mus musculus | 2 | ALA4619714 | organism-based format | Scientific Literature | |
16. | ALA4620098 | ADME | Tmax in ICR mouse at 50 mg/kg, po | Mus musculus | 2 | ALA4619714 | organism-based format | Scientific Literature | |
17. | ALA4620099 | ADME | Cmax in ICR mouse at 50 mg/kg, po | Mus musculus | 2 | ALA4619714 | organism-based format | Scientific Literature | |
18. | ALA4620100 | ADME | AUC (0 to t) in ICR mouse at 50 mg/kg, po | Mus musculus | 2 | ALA4619714 | organism-based format | Scientific Literature | |
19. | ALA4620101 | ADME | MRT in ICR mouse at 50 mg/kg, po | Mus musculus | 2 | ALA4619714 | organism-based format | Scientific Literature | |
20. | ALA4620110 | Functional | Antiviral activity against Hepatitis B virus infected in C57BL/6 mouse assessed as reduction in viral DNA at 0.93 mmol/kg, po administered bid and measured on day 2 by qRT-PCR analysis | Hepatitis B virus | 2 | ALA4619714 | organism-based format | Scientific Literature |