| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4433999 | A | Effect on IL-6 mRNA expression in TLR2-/- mouse BMDM cells at 0.1 to 1 uM by qRT-PCR analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA4434000 | F | Effect on IL-6 production in TLR2-/- mouse BMDM cells at 0.1 to 1 uM incubated for 24 hrs by ELISA | Mus musculus | 7 | cell-based format | Scientific Literature | ||
| 3. | ALA4434001 | F | Effect on TNFalpha production in TLR2-/- mouse BMDM cells at 0.1 to 1 uM incubated for 24 hrs by ELISA | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4434002 | B | Agonist activity at TLR2 in mouse BV2 cells assessed as increase in IL-6 secretion at 1 uM incubated for 24 hrs in presence of NF-kappaB inhibitor triptolide by ELISA | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA4434003 | B | Activation of TLR2 in in wild type mouse BMDM cells assessed as stimulation of IL-6 production at 0.1 to 1 uM incubated for 24 hrs by ELISA | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA4434004 | A | Effect on IL-6 mRNA expression in TLR2-/- mouse BMDM cells at 0.1 to 1 uM by qRT-PCR analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 7. | ALA4434005 | B | Agonist activity at TLR2 in wild type mouse BMDM cells assessed as induction of NFkappaB pathway activation by measuring increase in IL-6 mRNA expression by qRT-PCR analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 8. | ALA4434006 | B | Agonist activity at TLR2 in mouse dendritic cells assessed as upregulation CD80 expression at 100 ng/ml by flow cytometry | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA4434013 | B | Agonist activity at TLR2/1 in PMA-differentiated human THP-1 cells assessed as induction of IL-6 production at 2.5 uM incubated for 24 hrs after preincubation with anti-hTLR2-IGA for 2 hrs by ELISA | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 10. | ALA4434014 | B | Agonist activity at TLR2/1 in PMA-differentiated human THP-1 cells assessed as induction of IL-6 production at 2.5 uM incubated for 24 hrs after preincubation with anti-hTLR1-IGG for 2 hrs by ELISA | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA4434015 | B | Agonist activity at TLR2/6 in PMA-differentiated human THP-1 cells assessed as induction of IL-6 production at 2.5 uM incubated for 24 hrs after preincubation with anti-hTLR6-IGG for 2 hrs by ELISA | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4434019 | A | Cytotoxicity against mouse BV2 cells assessed as cell viability up to 5 uM incubated for 24 hrs by CCK-8 assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 13. | ALA4434020 | B | Agonist activity at TLR2 in mouse BV2 cells assessed as increase in IL-6 secretion at 2 uM incubated for 24 hrs by ELISA | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 14. | ALA4434022 | B | Activation of TLR2 in in wild type mouse BMDM cells assessed as stimulation of IL-12 production at 0.1 to 1 uM incubated for 24 hrs by ELISA | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA4434023 | B | Activation of TLR2 in in wild type mouse BMDM cells assessed as stimulation of TNFalpha production at 0.1 to 1 uM incubated for 24 hrs by ELISA | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA4434024 | A | Effect on IkappaBalpha protein expression in mouse BV2 cells at 0.2 to 2 uM incubated for 12 hrs by Western blot analysis | Mus musculus | 3 | cell-based format | Scientific Literature |
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