# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4321030 | Functional | Induction of apoptosis in human SW620 cells assessed as Bcl-xl protein level at 15 uM measured after 48 hrs by Western blot analysis relative to beta-actin (Rvb = 1 No_unit) | Homo sapiens | 4 | ALA4316609 | cell-based format | Scientific Literature | |
2. | ALA4321031 | Functional | Induction of apoptosis in human SW620 cells assessed as Bcl-xl protein level at 10 uM measured after 48 hrs by Western blot analysis relative to beta-actin (Rvb = 1 No_unit) | Homo sapiens | 4 | ALA4316609 | cell-based format | Scientific Literature | |
3. | ALA4321033 | Functional | Cytotoxicity against human A431 cells measured after 48 hrs by MTT assay | Homo sapiens | 48 | ALA4316609 | cell-based format | Scientific Literature | |
4. | ALA4321034 | Functional | Cytotoxicity against human SA cells measured after 48 hrs by MTT assay | Homo sapiens | 48 | ALA4316609 | cell-based format | Scientific Literature | |
5. | ALA4321035 | Functional | Cytotoxicity against human MCF7 cells measured after 48 hrs by MTT assay | Homo sapiens | 48 | ALA4316609 | cell-based format | Scientific Literature | |
6. | ALA4321036 | Functional | Cytotoxicity against human SiHa cells measured after 48 hrs by MTT assay | Homo sapiens | 48 | ALA4316609 | cell-based format | Scientific Literature | |
7. | ALA4321037 | Functional | Cytotoxicity against human SW620 cells measured after 48 hrs by MTT assay | Homo sapiens | 48 | ALA4316609 | cell-based format | Scientific Literature | |
8. | ALA4321039 | Functional | Induction of apoptosis in human SW620 cells assessed as XIAP protein level at 10 uM measured after 48 hrs by Western blot analysis relative to beta-actin (Rvb = 1 No_unit) | Homo sapiens | 4 | ALA4316609 | cell-based format | Scientific Literature | |
9. | ALA4321040 | Functional | Induction of apoptosis in human SW620 cells assessed as XIAP protein level at 15 uM measured after 48 hrs by Western blot analysis relative to beta-actin (Rvb = 1 No_unit) | Homo sapiens | 4 | ALA4316609 | cell-based format | Scientific Literature | |
10. | ALA4321041 | Functional | Induction of apoptosis in human SW620 cells assessed as XIAP protein level at 20 uM measured after 48 hrs by Western blot analysis relative to beta-actin (Rvb = 1 No_unit) | Homo sapiens | 4 | ALA4316609 | cell-based format | Scientific Literature | |
11. | ALA4321042 | Functional | Antitumor activity against human SW620 cells xenografted in athymic mouse assessed as suppression of tumor growth at 100 mg/kg administered as injection every other day for 15 days measured during compound dosing | Homo sapiens | 4 | ALA4316609 | organism-based format | Scientific Literature | |
12. | ALA4321043 | Toxicity | Toxicity in athymic mouse xenografted with human SW620 cells assessed as serum creatine level at 100 mg/kg administered as injection every other day for 15 days measured post last dose by ELISA (Rvb = 1.94 +/- 1.04 U/L) | Homo sapiens | 4 | ALA4316609 | organism-based format | Scientific Literature | |
13. | ALA4321049 | Functional | Induction of apoptosis in human SW620 cells assessed as Bcl-xl protein level at 20 uM measured after 48 hrs by Western blot analysis relative to beta-actin (Rvb = 1 No_unit) | Homo sapiens | 4 | ALA4316609 | cell-based format | Scientific Literature |