Inhibition of COX-1 in mouse J774 cells assessed as inhibition of PEG2 production using arachidonic acid as substrate pretreated for 15 mins followed by substrate addition measured after 30 mins by radioimmuno assay
Anti-inflammatory activity in rat assessed as effect on carrageenan-induced hyperalgesia by measuring paw pressure tolerance at 20 mg/kg, po administered as single dose preincubated with carrageenan for 4 hrs and followed by compound treatment and measured after 30 mins by paw-pressure test (Rvb = 33.9 +/- 3.7 g)
Anti-inflammatory activity in rat assessed as effect on carrageenan-induced hyperalgesia by measuring paw pressure tolerance at 20 mg/kg, po administered as single dose preincubated with carrageenan for 4 hrs and followed by compound treatment and measured after 60 mins by paw-pressure test (Rvb = 37.2 +/- 3.5 g)
Anti-inflammatory activity in rat assessed as effect on carrageenan-induced hyperalgesia by measuring paw pressure tolerance at 20 mg/kg, po administered as single dose preincubated with carrageenan for 4 hrs and followed by compound treatment and measured after 90 mins by paw-pressure test (Rvb = 36.7 +/- 4 g)
Antiinflammatory activity in rat assessed as effect on carrageenan-induced paw edema by measuring paw volume at 20 mg/kg, po administered as single dose preincubated with carrageenan for 4 hrs and followed by compound treatment and measured after 30 mins by plethysmometer (Rvb = 2.78 +/- 0.09 ml)
Antiinflammatory activity in rat assessed as inhibition of carrageenan-induced hyperalgesia at 20 mg/kg, po administered as single dose preincubated with carrageenan for 4 hrs and followed by compound treatment and measured after 2 hrs by paw-pressure test relative to untreated control
Antiinflammatory activity in rat assessed as inhibition of carrageenan-induced paw edema by measuring paw volume at 20 mg/kg, po administered as single dose preincubated with carrageenan for 4 hrs and followed by compound treatment and measured after 1 hr by plethysmometer relative to untreated control
Antinociceptive activity in Swiss albino mouse model of acetic-acid-induced writhing assessed as inhibition of writhing numbers at 10 mg/kg, po measured starting 5 mins post acetic acid challenge for 30 mins (Rvb = 30.5 +/- 3.7 No_unit)
Antinociceptive activity in Swiss albino mouse model of acetic-acid-induced writhing assessed as inhibition of writhing numbers at 20 mg/kg, po measured starting 5 mins post acetic acid challenge for 30 mins (Rvb = 30.5 +/- 3.7 No_unit)
Antinociceptive activity in Swiss albino mouse model of acetic-acid-induced writhing assessed as inhibition of writhing numbers at 40 mg/kg, po measured starting 5 mins post acetic acid challenge for 30 mins (Rvb = 30.5 +/- 3.7 No_unit)