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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4384730 ADME Clearance adjusted for unbound fraction in Sprague-Dawley rat at 1 mg/kg, iv administered as 30 mins infusion by LC/MS/MS analysis Rattus norvegicus 15 ALA4382258 organism-based format Scientific Literature 2. ALA4384732 ADME Clearance in Sprague-Dawley rat at 1 mg/kg, iv administered as 30 mins infusion by LC/MS/MS analysis Rattus norvegicus 15 ALA4382258 organism-based format Scientific Literature 3. ALA4384734 Binding Antagonist activity at human TRPV4 expressed in HEK cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10 mins followed by agonist addition by Fluo-4-AM dye-based FLIPR assay Homo sapiens 6 ALA4382258 cell-based format Scientific Literature 4. ALA4384735 ADME Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv or 2 mg/kg, po by LC/MS/MS analysis Rattus norvegicus 15 ALA4382258 organism-based format Scientific Literature 5. ALA4384736 ADME MRT in Sprague-Dawley rat at 1 mg/kg, iv or 2 mg/kg, po by LC/MS/MS analysis Rattus norvegicus 15 ALA4382258 organism-based format Scientific Literature 6. ALA4384737 ADME Oral bioavailability in Sprague-Dawley rat at 2 mg/kg by LC/MS/MS analysis Rattus norvegicus 15 ALA4382258 organism-based format Scientific Literature 7. ALA4384738 ADME Metabolic stability in rat liver microsomes assessed as parent compound remaining after 30 mins Rattus norvegicus 2 ALA4382258 microsome format Scientific Literature 8. ALA4384739 ADME Permeability of the compound by PAMPA 5 ALA4382258 assay format Scientific Literature 9. ALA4322927 Binding Antagonist activity at BacMam virus expressing human TRPV4 transduced in BHK/AC9 or HEK MSR2 cells assessed as inhibition of GSK634775-induced Ca2+ flux preincubated for 10 mins followed by agonist addition by Fluo-4 AM dye based FLIPR assay Homo sapiens 11 ALA4321813 cell-based format Scientific Literature 10. ALA4322928 Physicochemical Lipophilicity, log D of the compound at pH 7.4 by chromatographic method 11 ALA4321813 small-molecule physicochemical format Scientific Literature 11. ALA4322929 Physicochemical Solubility of the compound in FaSSIF measured after 4 hrs 13 ALA4321813 small-molecule physicochemical format Scientific Literature 12. ALA4322930 ADME MRT in Sprague-Dawley rat at 1 mg/kg, iv administered as 30 mins infusion by HPLC-MS/MS analysis Rattus norvegicus 10 ALA4321813 organism-based format Scientific Literature 13. ALA4322931 ADME Clearance in Sprague-Dawley rat at 1 mg/kg, iv administered as 30 mins infusion by HPLC-MS/MS analysis Rattus norvegicus 9 ALA4321813 organism-based format Scientific Literature 14. ALA4322932 ADME Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv administered as 30 mins infusion or 1 to 2 mg/kg, po by HPLC-MS/MS analysis Rattus norvegicus 11 ALA4321813 organism-based format Scientific Literature 15. ALA4322933 ADME Oral bioavailability in Sprague-Dawley rat at 1 to 2 mg/kg by HPLC-MS/MS analysis Rattus norvegicus 9 ALA4321813 organism-based format Scientific Literature 16. ALA4322934 ADME Protein binding in rat plasma assessed as unbound fraction Rattus norvegicus 9 ALA4321813 cell-free format Scientific Literature 17. ALA4322935 ADME Unbound clearance in Sprague-Dawley rat at 1 mg/kg, iv administered as 30 mins infusion by HPLC-MS/MS analysis Rattus norvegicus 10 ALA4321813 organism-based format Scientific Literature 18. ALA4322936 ADME Unbound volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv administered as 30 mins infusion or 1 to 2 mg/kg, po by HPLC-MS/MS analysis Rattus norvegicus 11 ALA4321813 organism-based format Scientific Literature