# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4375994 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in fibronectin expression at 50 uM measured after 12 hrs by Western blot analysis | Rattus norvegicus | 31 | ALA4373718 | assay format | Scientific Literature | |
2. | ALA4375995 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in fibronectin expression at 10 uM measured after 12 hrs by Western blot analysis relative to control | Rattus norvegicus | 31 | ALA4373718 | assay format | Scientific Literature | |
3. | ALA4375996 | ADME | Cytotoxicity against Sprague-Dawley rat cardiac fibroblasts assessed as reduction in cell viability at 25 uM measured after 48 hrs by MTT assay | Rattus norvegicus | 1 | ALA4373718 | assay format | Scientific Literature | |
4. | ALA4375997 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in fibronectin expression measured after 12 hrs by Western blot analysis | Rattus norvegicus | 1 | ALA4373718 | assay format | Scientific Literature | |
5. | ALA4375998 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in alpha-SMA expression measured after 12 hrs by Western blot analysis | Rattus norvegicus | 1 | ALA4373718 | assay format | Scientific Literature | |
6. | ALA4375999 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in collagen 1 expression measured after 12 hrs by Western blot analysis | Rattus norvegicus | 1 | ALA4373718 | assay format | Scientific Literature | |
7. | ALA4376000 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in collagen 3 expression measured after 12 hrs by Western blot analysis | Rattus norvegicus | 1 | ALA4373718 | assay format | Scientific Literature | |
8. | ALA4376001 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in fibronectin mRNA expression at 2.5 to 10 uM measured after 12 hrs by qRT-PCR analysis | Rattus norvegicus | 1 | ALA4373718 | assay format | Scientific Literature | |
9. | ALA4376002 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in alpha-SMA mRNA expression at 2.5 to 10 uM measured after 12 hrs by qRT-PCR analysis | Rattus norvegicus | 1 | ALA4373718 | assay format | Scientific Literature | |
10. | ALA4376003 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in collagen 1 mRNA expression at 2.5 to 10 uM measured after 12 hrs by qRT-PCR analysis | Rattus norvegicus | 1 | ALA4373718 | assay format | Scientific Literature | |
11. | ALA4376004 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in collagen 3 mRNA expression at 2.5 to 10 uM measured after 12 hrs by qRT-PCR analysis | Rattus norvegicus | 1 | ALA4373718 | assay format | Scientific Literature | |
12. | ALA4376005 | ADME | Effect on total Smad3 expression in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts at 10 uM measured after 5 to 30 mins by Western blot analysis | Rattus norvegicus | 1 | ALA4373718 | assay format | Scientific Literature | |
13. | ALA4376006 | ADME | Effect on total Smad2 expression in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts at 10 uM measured after 5 to 30 mins by Western blot analysis | Rattus norvegicus | 1 | ALA4373718 | assay format | Scientific Literature | |
14. | ALA4376007 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in Smad3 phosphorylation at 10 uM measured after 5 to 30 mins by Western blot analysis | Rattus norvegicus | 1 | ALA4373718 | single protein format | Scientific Literature | |
15. | ALA4376008 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in Smad2 phosphorylation at 10 uM measured after 5 to 30 mins by Western blot analysis | Rattus norvegicus | 1 | ALA4373718 | single protein format | Scientific Literature | |
16. | ALA4376021 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in Smad2 nuclear translocation at 10 uM measured after 5 mins by Western blot analysis | Rattus norvegicus | 1 | ALA4373718 | single protein format | Scientific Literature | |
17. | ALA4376022 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in Smad3 nuclear translocation at 10 uM measured after 5 mins by Western blot analysis | Rattus norvegicus | 1 | ALA4373718 | single protein format | Scientific Literature | |
18. | ALA4376023 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in Smad2 nuclear translocation at 10 uM measured after 5 mins by DAPI staining-based laser confocal microscopic analysis | Rattus norvegicus | 1 | ALA4373718 | single protein format | Scientific Literature | |
19. | ALA4376024 | Binding | Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in Smad3 nuclear translocation at 10 uM measured after 5 mins by DAPI staining-based laser confocal microscopic analysis | Rattus norvegicus | 1 | ALA4373718 | single protein format | Scientific Literature | |
20. | ALA4376025 | Functional | Effect on TGFbeta1 receptor expression in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts at 2.5 to 10 uM measured after 5 mins by Western blot analysis | Rattus norvegicus | 1 | ALA4373718 | assay format | Scientific Literature |