# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4314273 | Functional | Induction of H2S generation in mouse BV2 cells at 100 uM after 45 mins by WSP-1 fluorescence dye based spectrofluorimetric analysis | Mus musculus | 8 | ALA4311984 | cell-based format | Scientific Literature | |
2. | ALA4314275 | Functional | Cytoprotection against LPS-induced cell damage in mouse BV2 cells assessed as cell viability at 1 uM preincubated with compound for 1 hr followed by LPS addition and measured after 24 hrs by cell analyser based assay (Rvb = 80.6 +/- 1.2%) | Mus musculus | 2 | ALA4311984 | cell-based format | Scientific Literature | |
3. | ALA4314276 | Functional | Antioxidant activity in mouse BV2 cells assessed as reduction in LPS-induced ROS release at 1 uM preincubated with compound for 1 hr followed by LPS addition and measured after 24 hrs by cell analyser based assay (Rvb = 154 +/- 3.8%) | Mus musculus | 6 | ALA4311984 | cell-based format | Scientific Literature | |
4. | ALA4314278 | Functional | Inhibition of LPS-induced nitric oxide in mouse BV2 cells assessed as intracellular nitric oxide level at 1 uM preincubated with compound for 1 hr followed by LPS addition and measured after 24 hrs by cell analyser based assay (Rvb = 145.7 +/- 4.4%) | Mus musculus | 3 | ALA4311984 | cell-based format | Scientific Literature | |
5. | ALA4314279 | ADME | Cytotoxicity against human SH-SY5Y cells assessed as cell viability up to 5 uM after 24 hrs by MTT assay | Homo sapiens | 6 | ALA4311984 | cell-based format | Scientific Literature | |
6. | ALA4314280 | Functional | Antioxidant activity in human SH-SY5Y cells assessed as inhibition of H2O2-induced intracellular ROS generation at 5 uM preincubated with compound for 24 hrs followed by H2O2 addition after 30 mins by DCFH-DA dye based fluorescence assay | Homo sapiens | 2 | ALA4311984 | cell-based format | Scientific Literature | |
7. | ALA4314281 | Functional | Antioxidant activity in human SH-SY5Y cells assessed as inhibition of tert-butyl hydroperoxide-induced intracellular ROS generation at 5 uM preincubated with compound for 24 hrs followed by tert-butyl hydroperoxide addition after 30 mins by DCFH-DA dye based fluorescence assay | Homo sapiens | 2 | ALA4311984 | cell-based format | Scientific Literature | |
8. | ALA4314282 | Functional | Antioxidant activity in human SH-SY5Y cells assessed as increase in GSH level at 5 uM after 24 hrs by MCB-dye based fluorescence assay relative to control | Homo sapiens | 2 | ALA4311984 | cell-based format | Scientific Literature | |
9. | ALA4314283 | Binding | Activation of Nrf2 in human SH-SY5Y cells at 5 uM after 1 to 6 hrs by ELISA method | Homo sapiens | 2 | ALA4311984 | cell-based format | Scientific Literature | |
10. | ALA4314284 | Functional | Neuroprotection against amyloid beta (1 to 42 residues)-induced toxicity in human SH-SY5Y cells preincubated for 24 hrs followed by amyloid beta addition and measured after 4 hrs by MTT-based exocytosis assay | Homo sapiens | 6 | ALA4311984 | cell-based format | Scientific Literature | |
11. | ALA4314285 | Functional | Inhibition of LPS-induced nitric oxide in mouse BV2 cells assessed as reduction in intracellular nitric oxide level at 1 uM preincubated with compound for 1 hr followed by LPS addition and measured after 24 hrs by cell analyser based assay (Rvb = 145.7 +/- 4.4%) | Mus musculus | 7 | ALA4311984 | cell-based format | Scientific Literature |