| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4430204 | A | Drug uptake in mitochondria of erlotinib-resistant human HCC827B cells assessed as R1 gated population at 4 uM after 1 hr by MTR staining based FACS analysis (Rvb = >98%) | Homo sapiens | 2 | mitochondrion format | Scientific Literature | ||
| 2. | ALA4430205 | A | Drug uptake in mitochondria of erlotinib-resistant human HCC827B cells assessed as R1 gated population at 4 uM after 1 hr by FACS analysis (Rvb = >98%) | Homo sapiens | 1 | mitochondrion format | Scientific Literature | ||
| 3. | ALA4430208 | F | Cytotoxicity against erlotinib-sensitive human HCC827A cells assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4430209 | F | Cytotoxicity against erlotinib-resistant human HCC827B cells expressing MET assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4430210 | A | Cytotoxicity against TAMH assessed as reduction in cell viability after 24 hrs by cell titer glo based luminescence assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4430211 | F | Induction of apoptosis in erlotinib-resistant human HCC827B cells assessed as increase in cleaved PARP level at 4 uM measured up to 60 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA4430212 | F | Induction of apoptosis in erlotinib-resistant human HCC827B cells assessed as increase in cleaved caspase 3 level at 4 uM measured up to 60 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA4430213 | F | Induction of apoptosis in erlotinib-resistant human HCC827B cells assessed as increase in cleaved caspase 7 level at 4 uM measured up to 60 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA4430214 | A | Drug uptake in mitochondria of human HeLa cells at 4 uM after 3 hrs by MTR dye/Hoechst 33342 staining based confocal microscopy | Homo sapiens | 2 | mitochondrion format | Scientific Literature | ||
| 10. | ALA4430215 | A | Effect on total MET expression level in erlotinib-resistant human HCC827B cells at 4 uM after 1 to 1.5 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4430216 | A | Effect on total MET expression level in mitochondria isolated from erlotinib-resistant human HCC827B cells at 4 uM after 1 to 1.5 hrs by immunoblot analysis | Homo sapiens | 2 | mitochondrion format | Scientific Literature | ||
| 12. | ALA4430217 | B | Inhibition of MET phosphorylation at Y1234/1235 in erlotinib-resistant human HCC827B cells at 4 uM after 1 to 1.5 hrs by immunoblot analysis | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 13. | ALA4430218 | B | Inhibition of MET phosphorylation at Y1234/1235 in mitochondria isolated from erlotinib-resistant human HCC827B cells at 4 uM after 1 to 1.5 hrs by immunoblot analysis | Homo sapiens | 2 | mitochondrion format | Scientific Literature | ||
| 14. | ALA4430219 | B | Inhibition of MET phosphorylation at Y1234/1235 in erlotinib-resistant human HCC827B cells at 4 uM after 24 hrs by immunoblot analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA4430220 | B | Inhibition of MET phosphorylation at Y1234/1235 in mitochondria isolated from compound treated erlotinib-resistant human HCC827B cells at 4 uM after 24 hrs by immunoblot analysis | Homo sapiens | 2 | mitochondrion format | Scientific Literature |
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