# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4385407 | Functional | Antileishmanial activity against promastigote stage of Leishmania donovani MHOM/IN/00/DEVI after 72 hrs by MTT assay | Leishmania donovani | 30 | ALA4382286 | organism-based format | Scientific Literature | |
2. | ALA4385408 | ADME | Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay | Homo sapiens | 34 | ALA4382286 | cell-based format | Scientific Literature | |
3. | ALA4385409 | Physicochemical | Solubility of the compound in RPMI medium at 4 to 6 uM | 11 | ALA4382286 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4385410 | Toxicity | Selectivity index, ratio of CC50 for human HepG2 cells to IC50 for promastigote stage of Leishmania donovani MHOM/IN/00/DEVI | 26 | ALA4382286 | assay format | Scientific Literature | ||
5. | ALA4385411 | Functional | Antileishmanial activity against intracellular amastigote stage of Leishmania donovani infected in human THP1 cells after 120 hrs by giemsa staining based microscopic analysis | Leishmania donovani | 8 | ALA4382286 | organism-based format | Scientific Literature | |
6. | ALA4385412 | Functional | Antileishmanial activity against Leishmania infantum axenic amastigotes after 48 hrs by steady-glo luciferase reporter gene assay | Leishmania infantum | 8 | ALA4382286 | organism-based format | Scientific Literature | |
7. | ALA4385413 | Functional | Antileishmanial activity against promastigote stage of Leishmania major MHOM/IL/81/Friedlin after 72 hrs by MTT assay | Leishmania major | 3 | ALA4382286 | organism-based format | Scientific Literature | |
8. | ALA4385414 | Functional | Antileishmanial activity against intracellular amastigote stage of Leishmania major infected in human THP1 cells after 120 hrs by giemsa staining based microscopic analysis | Leishmania major | 3 | ALA4382286 | organism-based format | Scientific Literature | |
9. | ALA4385415 | Functional | Potency index, ratio of miltefosine IC50 to test compound IC50 for intracellular amastigote stage of Leishmania donovani infected in human THP1 cells | Leishmania donovani | 1 | ALA4382286 | organism-based format | Scientific Literature | |
10. | ALA4385416 | Functional | Potency index, ratio of fexinidazole IC50 to test compound IC50 for Leishmania infantum axenic amastigotes | Leishmania infantum | 1 | ALA4382286 | organism-based format | Scientific Literature | |
11. | ALA4385417 | Functional | Antiprotozoal activity against Trichomonas vaginalis TVR87 measured after 48 hrs by trypan blue assay | Trichomonas vaginalis | 3 | ALA4382286 | organism-based format | Scientific Literature | |
12. | ALA4385418 | Functional | Antiplasmodial activity against chloroquine/proguanil/pyrimethamine-resistant synchronized stage of Plasmodium falciparum K1 after 72 hrs by SYBR green1 staining based spectrophotometric method | Plasmodium falciparum | 2 | ALA4382286 | organism-based format | Scientific Literature | |
13. | ALA4385419 | Functional | Antitrypanosomal activity against trypomastigote stage of Trypanosoma brucei brucei AnTat 1.9 assessed as decrease in parasite viability after 69 hrs by Alamar Blue assay | Trypanosoma brucei brucei | 8 | ALA4382286 | organism-based format | Scientific Literature | |
14. | ALA4385420 | Functional | Antitrypanosomal activity against Trypanosoma cruzi MHOM/BR/78/Silvio cloneX10/7A epimastigotes measured after 4 days by resazurin dye based fluorescence assay | Trypanosoma cruzi | 5 | ALA4382286 | organism-based format | Scientific Literature | |
15. | ALA4385421 | ADME | Cytotoxicity against human THP1 cells after 72 hrs by MTT assay | Homo sapiens | 5 | ALA4382286 | cell-based format | Scientific Literature | |
16. | ALA4385422 | Physicochemical | Solubility of the compound in RPMI medium at >62.5 uM | 2 | ALA4382286 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA4385426 | ADME | Half life in CD-1 mouse hepatic microsomes in presence of NADPH by LC-MS/MS analysis | Mus musculus | 1 | ALA4382286 | microsome format | Scientific Literature | |
18. | ALA4385427 | ADME | Drug metabolism in CD-1 mouse hepatic microsomes assessed as 6-chloro-8-(4-chlorophenylsulfinyl)-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridine formation in presence of NADPH by LC-MS/MS analysis | Mus musculus | 1 | ALA4382286 | microsome format | Scientific Literature | |
19. | ALA4385428 | Toxicity | Mutagenicity in Salmonella typhimurium TA97a at 62.5 to 625 uM preincubated for 1 hr followed by addition of molten top agar and measured 48 hrs post dark incubation by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 3 | ALA4382286 | assay format | Scientific Literature | |
20. | ALA4385429 | Toxicity | Mutagenicity in Salmonella typhimurium TA98 at 62.5 to 625 uM preincubated for 1 hr followed by addition of molten top agar and measured 48 hrs post dark incubation by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 3 | ALA4382286 | assay format | Scientific Literature |