| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4399712 | F | Potentiation of cisplatin-induced apoptosis in human Cal27CisR cells assessed as caspase-3/7 activity at 1 uM preincubated for 48 hrs followed by cisplatin addition and further incubation for 24 hrs treated with 20 uM pan capsase inhibitor QVD for 30 mins prior to compound addition by CellEvent caspase 3/7 green detection reagent/Hoechst 33342 staining based arrayscan analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 2. | ALA4399713 | F | Potentiation of cisplatin-induced apoptosis in human CAL27 cells assessed as caspase-3/7 activity at 0.5 uM preincubated for 48 hrs followed by cisplatin addition and further incubation for 24 hrs treated with 20 uM pan capsase inhibitor QVD for 30 mins prior to compound addition by CellEvent caspase 3/7 green detection reagent/Hoechst 33342 staining based arrayscan analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA4399714 | F | Potentiation of cisplatin-induced apoptosis in human Cal27CisR cells assessed as increase in caspase-3/7 activation at 1 uM preincubated for 48 hrs followed by cisplatin addition and further incubation for 24 hrs by CellEvent caspase 3/7 green detection reagent/Hoechst 33342 staining based arrayscan analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4399715 | F | Potentiation of cisplatin-induced apoptosis in human CAL27 cells assessed as increase in caspase-3/7 activation at 0.5 uM preincubated for 48 hrs followed by cisplatin addition and further incubation for 24 hrs by CellEvent caspase 3/7 green detection reagent/Hoechst 33342 staining based arrayscan analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4399716 | F | Induction of apoptosis in human Cal27CisR cells assessed as increase in caspase-3/7 activation at 1 uM after 48 hrs by CellEvent caspase 3/7 green detection reagent/Hoechst 33342 staining based arrayscan analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4399717 | F | Induction of apoptosis in human CAL27 cells assessed as caspase-3/7 activity at 0.5 uM after 48 hrs by CellEvent caspase 3/7 green detection reagent/Hoechst 33342 staining based arrayscan analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA4399718 | F | Potentiation of cisplatin-induced apoptosis in human Cal27CisR cells assessed as accumulation at sub-G1 phase at 1 uM preincubated for 48 hrs followed by cisplatin addition and further incubation for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 8.3 +/- 1.06%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA4399719 | F | Potentiation of cisplatin-induced apoptosis in human CAL27 cells assessed as increase in accumulation at sub-G1 phase at 0.5 uM preincubated for 48 hrs followed by cisplatin addition and further incubation for 24 hrs by propidium iodide staining based flow cytometry relative to cisplatin alone | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA4399720 | F | Potentiation of cisplatin-induced apoptosis in human CAL27 cells assessed as accumulation at sub-G1 phase at 0.5 uM preincubated for 48 hrs followed by cisplatin addition and further incubation for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 11.5 +/- 0.89%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4399721 | F | Induction of apoptosis in human CAL27 cells assessed as accumulation at sub-G1 phase at 0.5 uM after 48 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4399722 | F | Potentiation of cisplatin-induced apoptosis in human Cal27CisR cells assessed as increase in accumulation at sub-G1 phase at 1 uM preincubated for 48 hrs followed by cisplatin addition and further incubation for 24 hrs by propidium iodide staining based flow cytometry relative to cisplatin alone | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4399723 | F | Induction of apoptosis in human Cal27CisR cells assessed as accumulation at sub-G1 phase at 1 uM after 48 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4399724 | F | Potentiation of cisplatin-induced cytotoxicity in human Cal27CisR cells assessed as fold reduction in cisplatin IC50 at 1 uM preincubated for 48 hrs followed by cisplatin addition and further incubation for 72 hrs by MTT assay relative to cisplatin alone | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4399725 | F | Potentiation of cisplatin-induced cytotoxicity in human CAL27 cells assessed as fold reduction in cisplatin IC50 at 0.5 uM preincubated for 48 hrs followed by cisplatin addition and further incubation for 72 hrs by MTT assay relative to cisplatin alone | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4399726 | F | Potentiation of cisplatin-induced cytotoxicity in human Cal27CisR cells assessed as cisplatin IC50 at 1 uM preincubated for 48 hrs followed by cisplatin addition and further incubation for 72 hrs by MTT assay (Rvb = 37.3 uM) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4399727 | F | Potentiation of cisplatin-induced cytotoxicity in human CAL27 cells assessed as cisplatin IC50 at 0.5 uM preincubated for 48 hrs followed by cisplatin addition and further incubation for 72 hrs by MTT assay (Rvb = 13.2 uM) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4399728 | B | Selectivity index, ratio of IC50 for C-terminal His-fusion tagged/N-terminal Strep-2 tagged recombinant human HDAC8 (1 to 377 residues) expressed in insect cells to IC50 for C-terminal GST-tagged recombinant human HDAC2 (1 to 488 residues) expressed in Baculovirus infected insect cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 18. | ALA4399729 | B | Selectivity index, ratio of IC50 for C-terminal His-tagged/N-terminal GST-tagged recombinant human HDAC4 (627 to 1084 residues) expressed in Baculovirus infected insect cells to IC50 for C-terminal GST-tagged recombinant human HDAC2 (1 to 488 residues) expressed in Baculovirus infected insect cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA4399730 | B | Inhibition of C-terminal His-fusion tagged/N-terminal Strep-2 tagged recombinant human HDAC8 (1 to 377 residues) expressed in insect cells using Boc-Lys(TFa)-AMC as substrate preincubated for 5 mins followed by substrate addition and further incubation for 90 mins measured after 15 mins by microplate reader based fluorescence assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 20. | ALA4399731 | B | Inhibition of N-terminal GST-tagged recombinant human HDAC6 (1 to 1215 residues) expressed in Baculovirus infected insect cells using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and further incubation for 90 mins measured after 15 mins by microplate reader based fluorescence assay | Homo sapiens | 7 | cell-based format | Scientific Literature |
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