# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4478076 | B | Antagonist activity at recombinant rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular calcium accumulation preincubated for 5 mins followed by icilin addition by Fluo-4-AM probe-based spectrofluorimetric assay | Rattus norvegicus | 39 | ALA4477204 | cell-based format | Scientific Literature | |
2. | ALA4478077 | B | Agonist activity at recombinant rat TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo-4-AM probe-based spectrofluorimetric assay | Rattus norvegicus | 39 | ALA4477204 | cell-based format | Scientific Literature | |
3. | ALA4478078 | B | Agonist activity at recombinant rat TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo-4-AM probe-based spectrofluorimetric assay relative to ionomycin | Rattus norvegicus | 39 | ALA4477204 | cell-based format | Scientific Literature | |
4. | ALA4478079 | F | Cytotoxicity against human LNCAP cells assessed as inhibition of cell growth at 10 uM after 72 hrs by trypan blue assay | Homo sapiens | 4 | ALA4477204 | cell-based format | Scientific Literature | |
5. | ALA4478083 | F | Induction of apoptosis in human LNCAP cells assessed as increase in caspase3/7 activity at 10 uM after 72 hrs by caspase-glo 3/7 chemiluminescence assay relative to control | Homo sapiens | 4 | ALA4477204 | cell-based format | Scientific Literature | |
6. | ALA4478084 | A | Intrinsic clearance in C57BL/6 mouse liver microsomes at 3 uM measured over 60 mins by HPLC analysis | Mus musculus | 7 | ALA4477204 | microsome format | Scientific Literature | |
7. | ALA4478085 | P | Aqueous solubility of compound in water at 37 degC after 48 hrs by HPLC analysis | 4 | ALA4477204 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4478088 | B | Antagonist activity at recombinant rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced intracellular calcium accumulation preincubated for 5 mins followed by AITC addition by Fluo-4-AM probe-based spectrofluorimetric assay | Rattus norvegicus | 4 | ALA4477204 | cell-based format | Scientific Literature | |
9. | ALA4478089 | B | Antagonist activity at recombinant human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular calcium accumulation preincubated for 5 mins followed by capsaicin addition by Fluo-4-AM probe-based spectrofluorimetric assay | Homo sapiens | 4 | ALA4477204 | cell-based format | Scientific Literature | |
10. | ALA4478090 | B | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced intracellular calcium accumulation preincubated for 5 mins followed by LPC addition by Fluo-4-AM probe-based spectrofluorimetric assay | Rattus norvegicus | 4 | ALA4477204 | cell-based format | Scientific Literature | |
11. | ALA4478091 | B | Antagonist activity at recombinant rat TRPV3 expressed in HEK293 cells assessed as inhibition of thymol-induced intracellular calcium accumulation preincubated for 5 mins followed by thymol addition by Fluo-4-AM probe-based spectrofluorimetric assay | Rattus norvegicus | 4 | ALA4477204 | cell-based format | Scientific Literature | |
12. | ALA4478092 | B | Antagonist activity at recombinant rat TRPV4 expressed in HEK293 cells assessed as inhibition of 4alphaPDD-induced intracellular calcium accumulation preincubated for 5 mins followed by 4alphaPDD addition by Fluo-4-AM probe-based spectrofluorimetric assay | Rattus norvegicus | 4 | ALA4477204 | cell-based format | Scientific Literature | |
13. | ALA4478093 | B | Selectivity ratio of IC50 for recombinant rat TRPA1 expressed in HEK293 cells to IC50 for recombinant rat TRPM8 expressed in HEK293 cells | Rattus norvegicus | 4 | ALA4477204 | cell-based format | Scientific Literature | |
14. | ALA4478094 | B | Antagonist activity at recombinant rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced intracellular calcium accumulation up to 10 uM preincubated for 5 mins followed by AITC addition by Fluo-4-AM probe-based spectrofluorimetric assay | Rattus norvegicus | 4 | ALA4477204 | cell-based format | Scientific Literature | |
15. | ALA4478095 | B | Antagonist activity at recombinant human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular calcium accumulation up to 10 uM rat preincubated for 5 mins followed by capsaicin addition by Fluo-4-AM probe-based spectrofluorimetric assay | Homo sapiens | 4 | ALA4477204 | cell-based format | Scientific Literature | |
16. | ALA4478096 | B | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced intracellular calcium accumulation up to 10 uM preincubated for 5 mins followed by LPC addition by Fluo-4-AM probe-based spectrofluorimetric assay | Rattus norvegicus | 4 | ALA4477204 | cell-based format | Scientific Literature | |
17. | ALA4478097 | B | Antagonist activity at recombinant rat TRPV3 expressed in HEK293 cells assessed as inhibition of thymol-induced intracellular calcium accumulation up to 10 uM preincubated for 5 mins followed by thymol addition by Fluo-4-AM probe-based spectrofluorimetric assay | Rattus norvegicus | 4 | ALA4477204 | cell-based format | Scientific Literature | |
18. | ALA4478098 | B | Antagonist activity at recombinant rat TRPV4 expressed in HEK293 cells assessed as inhibition of 4alphaPDD-induced intracellular calcium accumulation up to 10 uM preincubated for 5 mins followed by 4alphaPDD addition by Fluo-4-AM probe-based spectrofluorimetric assay | Rattus norvegicus | 4 | ALA4477204 | cell-based format | Scientific Literature | |
19. | ALA4478099 | B | Selectivity ratio of IC50 for recombinant human TRPV1 expressed in HEK293 cells to IC50 for recombinant rat TRPM8 expressed in HEK293 cells | 4 | ALA4477204 | cell-based format | Scientific Literature | ||
20. | ALA4478100 | B | Selectivity ratio of IC50 for recombinant rat TRPV2 expressed in HEK293 cells to IC50 for recombinant rat TRPM8 expressed in HEK293 cells | Rattus norvegicus | 4 | ALA4477204 | cell-based format | Scientific Literature |