# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4325476 | Functional | Neuroprotective activity against oxygen-glucose deprivation-induced toxicity in human SH-SY5Y cells assessed as cell viability at 1 uM preincubated for 2 hrs followed by OGD-challenge and measured after 24 hrs by MTT assay (Rvb = 54.92 +/- 2.12%) | Homo sapiens | 30 | ALA4321877 | cell-based format | Scientific Literature | |
2. | ALA4325477 | Functional | Neuroprotective activity against oxygen-glucose deprivation-induced toxicity in human SH-SY5Y cells assessed as cell viability at 10 uM preincubated for 2 hrs followed by OGD-challenge and measured after 24 hrs by MTT assay (Rvb = 54.92 +/- 2.12%) | Homo sapiens | 30 | ALA4321877 | cell-based format | Scientific Literature | |
3. | ALA4325482 | ADME | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability at 10 uM measured after 24 hrs by MTT assay | Homo sapiens | 4 | ALA4321877 | cell-based format | Scientific Literature | |
4. | ALA4325484 | Functional | Neuroprotective activity against oxygen-glucose deprivation-induced toxicity in human SH-SY5Y cells assessed as cell viability at 2 uM preincubated for 2 hrs followed by OGD-challenge and measured after 24 hrs by MTT assay (Rvb = 54.92 +/- 2.12%) | Homo sapiens | 3 | ALA4321877 | cell-based format | Scientific Literature | |
5. | ALA4325485 | Functional | Neuroprotective activity against oxygen-glucose deprivation-induced toxicity in human SH-SY5Y cells assessed as cell viability at 4 uM preincubated for 2 hrs followed by OGD-challenge and measured after 24 hrs by MTT assay (Rvb = 54.92 +/- 2.12%) | Homo sapiens | 1 | ALA4321877 | cell-based format | Scientific Literature | |
6. | ALA4325486 | Functional | Antioxidant activity assessed as trolox equivalent of AAPH radical scavenging activity measured every min for 180 mins by ORAC-FL assay | 8 | ALA4321877 | assay format | Scientific Literature | ||
7. | ALA4325487 | ADME | Permeability of the compound incubated for 10 hrs by PAMPA | 8 | ALA4321877 | assay format | Scientific Literature | ||
8. | ALA4325488 | Physicochemical | Solubility of the compound in water incubated for 24 hrs by HPLC analysis | 4 | ALA4321877 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4325499 | Binding | Metal chelating activity of the compound assessed as formation of ferric-compound complex at 60 uM after 15 mins using ammonium iron citrate solution by UV-vis spectrophotometric method | 3 | ALA4321877 | assay format | Scientific Literature | ||
10. | ALA4325500 | Binding | Metal chelating activity of the compound assessed as formation of ferric-compound complex at 60 uM after 15 mins using FeSO4 solution by UV-vis spectrophotometric method | 3 | ALA4321877 | assay format | Scientific Literature | ||
11. | ALA4325501 | Binding | Metal chelating activity of the compound assessed as formation of ferric-compound complex at 60 uM after 15 mins using ammonium iron sulfate solution by UV-vis spectrophotometric method | 2 | ALA4321877 | assay format | Scientific Literature | ||
12. | ALA4325502 | Binding | Metal chelating activity of the compound assessed as formation of ferrous-compound complex at 60 uM after 15 mins using ammonium iron(II) sulfate solution by UV-vis spectrophotometric method | 2 | ALA4321877 | assay format | Scientific Literature | ||
13. | ALA4325503 | Binding | Metal chelating activity of the compound assessed as formation of ferric-compound complex at 60 uM after 15 mins using FeCl3 solution by UV-vis spectrophotometric method | 2 | ALA4321877 | assay format | Scientific Literature | ||
14. | ALA4325504 | Binding | Metal chelating activity of the compound assessed as formation of ferric-compound complex by measuring change in color at 60 uM after 15 mins using ammonium iron citrate solution by UV-vis spectrophotometric method | 2 | ALA4321877 | assay format | Scientific Literature | ||
15. | ALA4325505 | Binding | Metal chelating activity of the compound assessed as formation of ferric-compound complex by measuring change in color at 60 uM after 15 mins using FeSO4 solution by UV-vis spectrophotometric method | 2 | ALA4321877 | assay format | Scientific Literature |