| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4395839 | B | Inhibition of p38alpha MAPK (unknown origin) using ATF-2 as substrate after 1 hr by ELISA | Homo sapiens | 39 | ALA4393708 | single protein format | Scientific Literature | |
| 2. | ALA4395841 | B | Competitive inhibition of human recombinant full length GSK3beta using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated with enzyme for 10 mins followed by substrate and 25 uM ATP addition measured after 60 mins by ADP-Glo luminescence assay | Homo sapiens | 40 | ALA4393708 | single protein format | Scientific Literature | |
| 3. | ALA4395842 | B | Inhibition of human recombinant full length GSK3alpha using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated with enzyme for 10 mins followed by substrate and 25 uM ATP addition measured after 60 mins by ADP-Glo luminescence assay | Homo sapiens | 6 | ALA4393708 | single protein format | Scientific Literature | |
| 4. | ALA4395843 | B | Selectivity ratio, Ratio of IC50 for human recombinant full length GSK3alpha to IC50 for human recombinant full length GSK3beta using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated with enzyme for 10 mins followed by substrate and 25 uM ATP addition measured after 60 mins by ADP-Glo luminescence assay | Homo sapiens | 2 | ALA4393708 | assay format | Scientific Literature | |
| 5. | ALA4395844 | B | Competitive inhibition of human recombinant full length GSK3beta using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated with enzyme for 10 mins followed by substrate and 100 uM ATP addition measured after 60 mins by ADP-Glo luminescence assay | Homo sapiens | 2 | ALA4393708 | single protein format | Scientific Literature | |
| 6. | ALA4395845 | B | Competitive inhibition of human recombinant full length GSK3beta using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated with enzyme for 10 mins followed by substrate and 500 uM ATP addition measured after 60 mins by ADP-Glo luminescence assay | Homo sapiens | 2 | ALA4393708 | single protein format | Scientific Literature | |
| 7. | ALA4395846 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 10 mins by LC-MS analysis relative to control | Homo sapiens | 3 | ALA4393708 | microsome format | Scientific Literature | |
| 8. | ALA4395847 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 20 mins by LC-MS analysis relative to control | Homo sapiens | 3 | ALA4393708 | microsome format | Scientific Literature | |
| 9. | ALA4395848 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 30 mins by LC-MS analysis relative to control | Homo sapiens | 3 | ALA4393708 | microsome format | Scientific Literature | |
| 10. | ALA4395849 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 60 mins by LC-MS analysis relative to control | Homo sapiens | 3 | ALA4393708 | microsome format | Scientific Literature | |
| 11. | ALA4395850 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 120 mins by LC-MS analysis relative to control | Homo sapiens | 3 | ALA4393708 | microsome format | Scientific Literature | |
| 12. | ALA4395851 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 240 mins by LC-MS analysis relative to control | Homo sapiens | 4 | ALA4393708 | microsome format | Scientific Literature | |
| 13. | ALA4395854 | A | Drug uptake in RjOrl:Swiss CD-1 mouse brain at 10 mg/kg, iv administered as single dose measured after 2 hrs by LC-MS analysis | Mus musculus | 2 | ALA4393708 | organism-based format | Scientific Literature | |
| 14. | ALA4395855 | A | Plasma clearance in RjOrl:Swiss CD-1 mouse at 10 mg/kg, iv administered as single dose measured after 10 mins by LC-MS analysis | Mus musculus | 1 | ALA4393708 | organism-based format | Scientific Literature | |
| 15. | ALA4395856 | A | Plasma clearance in RjOrl:Swiss CD-1 mouse at 10 mg/kg, iv administered as single dose measured after 2 hrs by LC-MS analysis | Mus musculus | 1 | ALA4393708 | organism-based format | Scientific Literature | |
| 16. | ALA4395857 | F | Inhibition of LPS-induced TNFalpha production in human whole blood preincubated with compound for 15 mins followed by LPS addition measured after 2.5 hrs by ELISA | Homo sapiens | 3 | ALA4393708 | tissue-based format | Scientific Literature | |
| 17. | ALA4395858 | A | Inhibition of human recombinant CYP1A2 expressed in baculovirus infected insect cells using 3-cyano-7-ethoxycoumarin as substrate at 10 uM in presence of NADPH by fluorimetric analysis relative to control | Homo sapiens | 2 | ALA4393708 | cell-based format | Scientific Literature | |
| 18. | ALA4395859 | A | Inhibition of human recombinant CYP2C9 expressed in baculovirus infected insect cells using OOMR as substrate at 10 uM in presence of NADPH by fluorimetric analysis relative to control | Homo sapiens | 2 | ALA4393708 | cell-based format | Scientific Literature | |
| 19. | ALA4395860 | A | Inhibition of human recombinant CYP2C19 expressed in baculovirus infected insect cells using EOMCC as substrate in presence of NADPH by fluorimetric analysis relative to control | Homo sapiens | 2 | ALA4393708 | cell-based format | Scientific Literature | |
| 20. | ALA4395861 | A | Inhibition of human recombinant CYP2D6 expressed in baculovirus infected insect cells using EOMCC as substrate at 10 uM in presence of NADPH by fluorimetric analysis relative to control | Homo sapiens | 2 | ALA4393708 | cell-based format | Scientific Literature |
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