| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4345130 | Binding | Inhibition of recombinant full-length N-terminal His6-tagged human IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR peptide as substrate after 90 mins by fluorescence polarisation assay | Homo sapiens | 19 | ALA4342485 | assay format | Scientific Literature | |
| 2. | ALA4345131 | Binding | Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-6 production preincubated for 90 mins followed by R848 stimulation and measured after 3.5 hrs by MSD assay | Homo sapiens | 14 | ALA4342485 | tissue-based format | Scientific Literature | |
| 3. | ALA4345133 | Binding | Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-6 production preincubated for 90 mins followed by R848 stimulation and measured after 3.5 hrs by MSD assay relative to control | Homo sapiens | 14 | ALA4342485 | tissue-based format | Scientific Literature | |
| 4. | ALA4345135 | ADME | Apparent permeability across apical to basolateral side in dog MDCKI cells at 10 uM measured after 60 to 180 mins by lucifer yellow dye based LC-MS/MS analysis | Canis lupus familiaris | 13 | ALA4342485 | cell-based format | Scientific Literature |
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