# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4431785 | A | Protein binding in mouse plasma | Mus musculus | 2 | ALA4431312 | cell-free format | Scientific Literature | |
2. | ALA4431786 | B | Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporter gene assay | Toxoplasma gondii | 34 | ALA4431312 | single protein format | Scientific Literature | |
3. | ALA4431787 | B | Inhibition of chicken Src using AcEIYGEFKKK as substrate after 90 mins in presence of ATP by luciferase reporter gene assay | Gallus gallus | 32 | ALA4431312 | single protein format | Scientific Literature | |
4. | ALA4431788 | A | Cmin in BALB/c mouse plasma at 20 mg/kg, po administered on day 1 followed by 5 mg/kg every 24 hrs for 5 doses measured 24 hrs during compound dosing | Mus musculus | 2 | ALA4431312 | organism-based format | Scientific Literature | |
5. | ALA4431789 | A | Growth inhibition of human HepG2 cells after 48 hrs by Alamar blue assay | Homo sapiens | 30 | ALA4431312 | cell-based format | Scientific Literature | |
6. | ALA4431790 | A | Growth inhibition of human CRL8155 cells after 48 hrs by Alamar blue assay | Homo sapiens | 31 | ALA4431312 | assay format | Scientific Literature | |
7. | ALA4431791 | B | Inhibition of human ERG | Homo sapiens | 27 | ALA4431312 | single protein format | Scientific Literature | |
8. | ALA4431792 | F | Antiparasitic activity against Toxoplasma gondii infected in human foreskin fibroblasts assessed as reduction of parasite invasion after 44 hrs by beta-galactosidase reporter gene assay | Toxoplasma gondii | 30 | ALA4431312 | organism-based format | Scientific Literature | |
9. | ALA4431793 | B | Selectivity ratio of IC50 for chicken Src to IC50 for recombinant Toxoplasma gondii CDPK1 | 19 | ALA4431312 | assay format | Scientific Literature | ||
10. | ALA4431794 | P | Solubility of the compound in phosphate buffered saline at pH 6.5 by HPLC/UV analysis | 9 | ALA4431312 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA4431795 | A | Tmax in BALB/c mouse plasma at 10 mg/kg administered via oral gavage by LC/MS analysis | Mus musculus | 9 | ALA4431312 | organism-based format | Scientific Literature | |
12. | ALA4431796 | A | Cmax in BALB/c mouse plasma at 10 mg/kg administered via oral gavage by LC/MS analysis | Mus musculus | 9 | ALA4431312 | organism-based format | Scientific Literature | |
13. | ALA4431797 | A | AUC (0 to infinity) in BALB/c mouse plasma at 10 mg/kg administered via oral gavage by LC/MS analysis | Mus musculus | 9 | ALA4431312 | organism-based format | Scientific Literature | |
14. | ALA4431798 | A | Half life in BALB/c mouse plasma at 10 mg/kg administered via oral gavage by LC/MS analysis | Mus musculus | 9 | ALA4431312 | organism-based format | Scientific Literature | |
15. | ALA4431799 | A | Clearance in BALB/c mouse plasma at 10 mg/kg administered via oral gavage by LC/MS analysis | Mus musculus | 9 | ALA4431312 | organism-based format | Scientific Literature | |
16. | ALA4431800 | T | Toxicity in mouse at 10 mg/kg administered on day 1 | Mus musculus | 2 | ALA4431312 | organism-based format | Scientific Literature | |
17. | ALA4431801 | T | Toxicity in mouse assessed as overt toxicity at 50 mg/kg administered on day 4 followed by 100 mg/kg administered on day 8 pre-dosed with 10 mg/kg on day 1 measured up to 10 days during compound dosing | Mus musculus | 2 | ALA4431312 | organism-based format | Scientific Literature | |
18. | ALA4431802 | T | Toxicity in mouse assessed as weight loss at 50 mg/kg administered on day 4 followed by 100 mg/kg administered on day 8 pre-dosed with 10 mg/kg on day 1 measured up to 10 days during compound dosing | Mus musculus | 2 | ALA4431312 | organism-based format | Scientific Literature | |
19. | ALA4431803 | A | Plasma concentration required to maintain unbound plasma level above Toxoplasma gondii CDPK1 EC50 in mouse | Mus musculus | 2 | ALA4431312 | cell-free format | Scientific Literature | |
20. | ALA4431806 | A | AUC in Sprague-Dawley rat plasma at 5 mg/kg, iv administered for 3 mins by LC/MS analysis | Rattus norvegicus | 2 | ALA4431312 | organism-based format | Scientific Literature |