# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4356123 | Binding | Inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells assessed as reduction in conversion of L-tryptophan to N-formyl kynurenine using L-tryptophan as substrate after 30 mins by methylene blue dye based microplate reader analysis | Homo sapiens | 14 | ALA4354812 | cell-based format | Scientific Literature | |
2. | ALA4356124 | Binding | Inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in conversion of L-tryptophan to N-formyl kynurenine using L-tryptophan as substrate after 30 mins by methylene blue dye based microplate reader analysis | Homo sapiens | 13 | ALA4354812 | assay format | Scientific Literature | |
3. | ALA4356125 | Binding | Inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as reduction in conversion of L-tryptophan to N-formyl kynurenine using L-tryptophan as substrate after 30 mins by methylene blue assay | Homo sapiens | 14 | ALA4354812 | assay format | Scientific Literature | |
4. | ALA4356126 | Binding | Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells assessed as reduction in kynurenine production incubated for 18 hrs | Homo sapiens | 13 | ALA4354812 | cell-based format | Scientific Literature | |
5. | ALA4356127 | Binding | Inhibition of human IDO2 transfected in human U87MG cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated with for 6 hrs | Homo sapiens | 13 | ALA4354812 | cell-based format | Scientific Literature | |
6. | ALA4356128 | Binding | Inhibition of human TDO transfected in HEK293 cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 12 hrs | Homo sapiens | 14 | ALA4354812 | cell-based format | Scientific Literature | |
7. | ALA4356131 | Binding | Noncompetitive inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells assessed inhibition constant using varying concentration of L-tryptophan as substrate by Dixon plot analysis | Homo sapiens | 4 | ALA4354812 | cell-based format | Scientific Literature | |
8. | ALA4356136 | Binding | Mixed uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using varying concentration of L-tryptophan as substrate by Dixon plot analysis | Homo sapiens | 6 | ALA4354812 | assay format | Scientific Literature | |
9. | ALA4356137 | Binding | Noncompetitive inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using varying concentration of L-tryptophan as substrate by Dixon plot analysis | Homo sapiens | 3 | ALA4354812 | assay format | Scientific Literature | |
10. | ALA5216549 | Binding | Inhibition of IDO1 (unknown origin) | Homo sapiens | 4 | ALA5214930 | single protein format | Scientific Literature | |
11. | ALA5216550 | Binding | Inhibition of IDO2 (unknown origin) | Homo sapiens | 5 | ALA5214930 | single protein format | Scientific Literature | |
12. | ALA5216551 | Binding | Inhibition of TDO (unknown origin) | Homo sapiens | 1 | ALA5214930 | single protein format | Scientific Literature |