| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4339509 | A | Tmax in Sprague-Dawley rat at 50 mg/kg, po administered as single dose via gavage by LC/MS analysis | Rattus norvegicus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 2. | ALA4339510 | F | Antiinflammatory activity in C57BL/6J mouse model of MOG (35 to 55 residues)/pertussis toxin/complete Freund's adjuvant-induced experimental allergic encephalomyelitis assessed as effect on dendritic cell population in CNS by measuring change in CD11c level at 200 mg/kg, ig administered daily starting from 7 days post-immunization measured after 13 to 19 days post-immunization by flow cytometry analysis | Mus musculus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 3. | ALA4339511 | F | Antiinflammatory activity in C57BL/6J mouse model of MOG (35 to 55 residues)/pertussis toxin/complete Freund's adjuvant-induced experimental allergic encephalomyelitis assessed as effect on dendritic cell population in draining lymph nodes by measuring change in CD11c level at 200 mg/kg, ig administered daily starting from 7 days post-immunization measured after 13 to 19 days post-immunization by flow cytometry analysis | Mus musculus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 4. | ALA4339512 | F | Antiinflammatory activity in C57BL/6J mouse model of MOG (35 to 55 residues)/pertussis toxin/complete Freund's adjuvant-induced experimental allergic encephalomyelitis assessed as effect on dendritic cell population in spleen by measuring change in CD11c level at 200 mg/kg, ig administered daily starting from 7 days post-immunization measured after 13 to 19 days post-immunization by flow cytometry analysis | Mus musculus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 5. | ALA4339513 | F | Inhibition of M1 polarization in C57BL/6J mouse model of MOG (35 to 55 residues)/pertussis toxin/complete Freund's adjuvant-induced experimental allergic encephalomyelitis assessed as CD86 level in CNS at 200 mg/kg, ig administered daily starting from 7 days post-immunization measured after 13 to 19 days post-immunization by flow cytometry analysis (Rvb = 26.3%) | Mus musculus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 6. | ALA4339514 | F | Inhibition of M1 polarization in C57BL/6J mouse model of MOG (35 to 55 residues)/pertussis toxin/complete Freund's adjuvant-induced experimental allergic encephalomyelitis assessed as CD86 level in draining lymph nodes at 200 mg/kg, ig administered daily starting from 7 days post-immunization measured after 13 to 19 days post-immunization by flow cytometry analysis (Rvb = 18.4%) | Mus musculus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 7. | ALA4339515 | F | Inhibition of M1 polarization in C57BL/6J mouse model of MOG (35 to 55 residues)/pertussis toxin/complete Freund's adjuvant-induced experimental allergic encephalomyelitis assessed as CD86 level in spleen at 200 mg/kg, ig administered daily starting from 7 days post-immunization measured after 13 to 19 days post-immunization by flow cytometry analysis (Rvb = 11.8%) | Mus musculus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 8. | ALA4339516 | F | Induction of M2 polarization in C57BL/6J mouse model of MOG (35 to 55 residues)/pertussis toxin/complete Freund's adjuvant-induced experimental allergic encephalomyelitis assessed as CD206 level in CNS at 200 mg/kg, ig administered daily starting from 7 days post-immunization measured after 13 to 19 days post-immunization by flow cytometry analysis (Rvb = 7.8%) | Mus musculus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 9. | ALA4339517 | F | Induction of M2 polarization in C57BL/6J mouse model of MOG (35 to 55 residues)/pertussis toxin/complete Freund's adjuvant-induced experimental allergic encephalomyelitis assessed as CD206 level in draining lymph nodes at 200 mg/kg, ig administered daily starting from 7 days post-immunization measured after 13 to 19 days post-immunization by flow cytometry analysis (Rvb = 6.5%) | Mus musculus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 10. | ALA4339518 | F | Induction of M2 polarization in C57BL/6J mouse model of MOG (35 to 55 residues)/pertussis toxin/complete Freund's adjuvant-induced experimental allergic encephalomyelitis assessed as CD206 level in spleen at 200 mg/kg, ig administered daily starting from 7 days post-immunization measured after 13 to 19 days post-immunization by flow cytometry analysis (Rvb = 23.4%) | Mus musculus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 11. | ALA4339519 | F | Antiinflammatory activity in C57BL/6J mouse model of MOG (35 to 55 residues)/pertussis toxin/complete Freund's adjuvant-induced experimental allergic encephalomyelitis assessed as TH17 cell population in spinal cord by measuring IL17 level at 200 mg/kg, ig administered daily starting from 7 days post-immunization measured after 14 to 21 days post-immunization by flow cytometry analysis (Rvb = 7.7%) | Mus musculus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 12. | ALA4339520 | F | Antiinflammatory activity in C57BL/6J mouse model of MOG (35 to 55 residues)/pertussis toxin/complete Freund's adjuvant-induced experimental allergic encephalomyelitis assessed as TH1 cell population in spinal cord by measuring IFNgamma level at 200 mg/kg, ig administered daily starting from 7 days post-immunization measured after 14 to 21 days post-immunization by flow cytometry analysis (Rvb = 22.3%) | Mus musculus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 13. | ALA4339521 | F | Antiinflammatory activity in C57BL/6J mouse model of MOG (35 to 55 residues)/pertussis toxin/complete Freund's adjuvant-induced experimental allergic encephalomyelitis assessed as reduction in demyelination in spinal cord at 200 mg/kg, ig administered daily starting from 7 days post-immunization measured after 14 days post-immunization by H and E staining based microscopic analysis | Mus musculus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 14. | ALA4339522 | F | Antiinflammatory activity in C57BL/6J mouse model of MOG (35 to 55 residues)/pertussis toxin/complete Freund's adjuvant-induced experimental allergic encephalomyelitis assessed as reduction in infiltration in spinal cord at 200 mg/kg, ig administered daily starting from 7 days post-immunization measured after 14 days post-immunization by H and E staining based microscopic analysis | Mus musculus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 15. | ALA4339523 | F | Antiinflammatory activity in C57BL/6J mouse model of MOG (35 to 55 residues)/pertussis toxin/complete Freund's adjuvant-induced experimental allergic encephalomyelitis assessed as reduction in demyelination in spinal cord at 200 mg/kg, ig administered daily starting from 7 days post-immunization measured after 14 days post-immunization by LFB staining based microscopic analysis | Mus musculus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 16. | ALA4339524 | F | Antiinflammatory activity in C57BL/6J mouse model of MOG (35 to 55 residues)/pertussis toxin/complete Freund's adjuvant-induced experimental allergic encephalomyelitis assessed as reduction in infiltration in spinal cord at 200 mg/kg, ig administered daily starting from 7 days post-immunization measured after 14 days post-immunization by LFB staining based microscopic analysis | Mus musculus | 1 | ALA4339193 | organism-based format | Scientific Literature | |
| 17. | ALA4339525 | F | Inhibition of LPS-induced M1 polarization in C57BL/6J mouse BMDM cells assessed as down regulation of CD86 expression at 300 nM measured after 24 hrs by FACS analysis | Mus musculus | 1 | ALA4339193 | cell-based format | Scientific Literature | |
| 18. | ALA4339526 | F | Modulation of M2 polarization in C57BL/6J mouse BMDM cells assessed as up regulation of CD206 expression at 300 nM measured after 24 hrs by FACS analysis | Mus musculus | 1 | ALA4339193 | cell-based format | Scientific Literature | |
| 19. | ALA4339527 | A | Modulation of M1 polarization in C57BL/6J mouse BMDM cells assessed as up regulation of TNFalpha expression at 300 nM measured after 4 to 24 hrs by Western blot analysis | Mus musculus | 1 | ALA4339193 | cell-based format | Scientific Literature | |
| 20. | ALA4339528 | F | Modulation of M2 polarization in C57BL/6J mouse BMDM cells assessed as up regulation of YM1 expression at 300 nM measured after 4 to 24 hrs by Western blot analysis | Mus musculus | 1 | ALA4339193 | cell-based format | Scientific Literature |
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