# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4362496 | Binding | Inhibition of N-terminal His-tagged human JAK2 catalytic domain (826 to 1132 resiudes) expressed in baculovirus expression system at 100 nM using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr in presence of ATP by mobility shift assay relative to control | Homo sapiens | 38 | ALA4359878 | assay format | Scientific Literature | |
2. | ALA4362497 | Binding | Inhibition of N-terminal GST-tagged human FLT3 cytoplasmic domain (564 to 993 residues) expressed in baculovirus expression system at 100 nM using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr in presence of ATP by mobility shift assay relative to control | Homo sapiens | 38 | ALA4359878 | assay format | Scientific Literature | |
3. | ALA4362498 | Functional | Antiproliferative activity against human HEL cells assessed as growth inhibition after 72 hrs by CCK-8 assay | Homo sapiens | 15 | ALA4359878 | cell-based format | Scientific Literature | |
4. | ALA4362499 | Functional | Antiproliferative activity against human MV4-11 cells assessed as growth inhibition after 72 hrs by CCK-8 assay | Homo sapiens | 7 | ALA4359878 | cell-based format | Scientific Literature | |
5. | ALA4362500 | Functional | Antiproliferative activity against human HL60 cells assessed as growth inhibition after 72 hrs by CCK-8 assay | Homo sapiens | 7 | ALA4359878 | cell-based format | Scientific Literature | |
6. | ALA4362531 | Binding | Inhibition of N-terminal His-tagged human JAK2 catalytic domain (826 to 1132 resiudes) expressed in baculovirus expression system using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr in presence of ATP by mobility shift assay | Homo sapiens | 6 | ALA4359878 | assay format | Scientific Literature | |
7. | ALA4362532 | Binding | Inhibition of N-terminal GST-tagged human FLT3 cytoplasmic domain (564 to 993 residues) expressed in baculovirus expression system musing FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr in presence of ATP by mobility shift assay | Homo sapiens | 6 | ALA4359878 | assay format | Scientific Literature |