Inhibition of human COX1 assessed as reduction in PGF2alpha production using arachidonic acid as substrate preincubated with enzyme for 10 mins followed by substrate addition by ELISA
Inhibition of human COX2 assessed as reduction in PGF2alpha production using arachidonic acid as substrate preincubated with enzyme for 10 mins followed by substrate addition by ELISA
Antiinflammatory activity against carrageenan-induced albino Sprague-Dawley rat paw edema model assessed as paw diameter at 10 mg/kg, po pretreated for 1 hr followed by carrageenan challenge and measured immediately after carrageenan injection (Rvb = 3.46 +/- 0.08 mm)
Antiinflammatory activity against carrageenan-induced albino Sprague-Dawley rat paw edema model assessed as paw diameter at 10 mg/kg, po pretreated for 1 hr followed by carrageenan challenge and measured at 1 hr post-carrageenan injection (Rvb = 4.51 +/- 0.09 mm)
Antiinflammatory activity against carrageenan induced albino Sprague-Dawley rat paw edema model assessed as paw edema at 10 mg/kg, po pretreated for 1 hr followed by carrageenan challenge and measured at 1 hr post-carrageenan injection (Rvb = 30.3%)
Antiinflammatory activity against carrageenan induced albino Sprague-Dawley rat paw edema model assessed as paw diameter at 10 mg/kg, po pretreated for 1 hr followed by carrageenan challenge and measured at 2 hrs post-carrageenan injection (Rvb = 4.72 +/- 0.08 mm)
Antiinflammatory activity against carrageenan-induced albino Sprague-Dawley rat paw edema model assessed as paw edema at 10 mg/kg, po pretreated for 1 hr followed by carrageenan challenge and measured at 2 hrs post-carrageenan injection (Rvb = 36.4%)
Antiinflammatory activity against carrageenan induced albino Sprague-Dawley rat paw edema model assessed as paw diameter at 10 mg/kg, po pretreated for 1 hr followed by carrageenan challenge and measured at 3 hrs post-carrageenan injection (Rvb = 4.79 +/- 0.1 mm)
Antiinflammatory activity against carrageenan induced albino Sprague-Dawley rat paw edema model assessed as paw edema at 10 mg/kg, po pretreated for 1 hr followed by carrageenan challenge and measured at 3 hrs post-carrageenan injection (Rvb = 38.4%)
Antiinflammatory activity against carrageenan induced albino Sprague-Dawley rat paw edema model assessed as paw diameter at 10 mg/kg, po pretreated for 1 hr followed by carrageenan challenge and measured at 4 hrs post-carrageenan injection (Rvb = 4.88 +/- 0.1 mm)
Antiinflammatory activity against carrageenan induced albino Sprague-Dawley rat paw edema model assessed as paw edema at 10 mg/kg, po pretreated for 1 hr followed by carrageenan challenge and measured at 4 hrs post-carrageenan injection (Rvb = 41%)
Ulcerogenicity in albino rat assessed as gastric lesions at 10 mg/kg, po administered as single dose after 18 hrs of starvation challenge and measured after 4 hrs
Ulcerogenicity in albino rat assessed as severity of gastric lesions at 10 mg/kg, po administered as single dose after 18 hrs of starvation challenge and measured after 4 hrs