# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4345506 | B | Inhibition of heparanase (unknown origin) using biotin-heparan sulfate-Eu cryptate as substrate preincubated for 10 mins followed by substrate addition and measured after 60 mins by TR-FRET assay | Homo sapiens | 13 | ALA4342500 | single protein format | Scientific Literature | |
2. | ALA4345507 | A | Inhibition of coagulation factor 10a (unknown origin) incubated for 2 mins in presence of AT3 by chromogenic substrate based fluorescence assay | Homo sapiens | 2 | ALA4342500 | single protein format | Scientific Literature | |
3. | ALA4345508 | A | Inhibition of coagulation factor 2a (unknown origin) incubated for 2 mins in presence of AT3 by chromogenic substrate based fluorescence assay | Homo sapiens | 1 | ALA4342500 | single protein format | Scientific Literature | |
4. | ALA4345509 | B | Binding affinity to PF4 (unknown origin) by BLI assay | Homo sapiens | 1 | ALA4342500 | single protein format | Scientific Literature | |
5. | ALA4345510 | B | Inhibition of human recombinant heparanase assessed as reduction in [35S] labeled ECM degradation at 50 ug/ml incubated for 5 hrs relative to control | Homo sapiens | 1 | ALA4342500 | single protein format | Scientific Literature | |
6. | ALA4345511 | B | Inhibition of human recombinant heparanase assessed as reduction in [35S] labeled ECM degradation at 10 ug/ml incubated for 5 hrs relative to control | Homo sapiens | 1 | ALA4342500 | single protein format | Scientific Literature | |
7. | ALA4345512 | F | Inhibition of heparanase (unknown origin) assessed as reduction in ROS production in mouse MIN6 cells co-incubated with heparanase-producing CHO cells at 15 uM incubated for 24 hrs by mitochondrial ROS probe staining based fluorescence microscopic method | Mus musculus | 1 | ALA4342500 | cell-based format | Scientific Literature | |
8. | ALA4345513 | F | Inhibition of ROS production in mouse MIN6 cells at 15 uM incubated for 24 hrs by mitochondrial ROS probe staining based fluorescence microscopic method | Mus musculus | 1 | ALA4342500 | cell-based format | Scientific Literature | |
9. | ALA4345514 | B | Inhibition of heparanase (unknown origin) assessed as reduction in ROS-mediated SOD1 mRNA level in mouse MIN6 cells co-incubated with heparanase-producing CHO cells at 15 uM incubated for 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA4342500 | cell-based format | Scientific Literature | |
10. | ALA4345515 | B | Inhibition of heparanase (unknown origin) assessed as reduction in ROS-mediated ERO1alpha mRNA level in mouse MIN6 cells co-incubated with heparanase-producing CHO cells at 15 uM incubated for 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA4342500 | cell-based format | Scientific Literature | |
11. | ALA4345516 | F | Inhibition of ROS production in mouse MIN6 cells assessed as reduction in SOD1 mRNA level at 15 uM incubated for 24 hrs by qRT-PCR analysis | Mus musculus | 1 | ALA4342500 | cell-based format | Scientific Literature | |
12. | ALA4345517 | F | Inhibition of ROS production in mouse MIN6 cells assessed as reduction in ERO1alpha mRNA level at 15 uM incubated for 24 hrs by qRT-PCR analysis | Mus musculus | 1 | ALA4342500 | cell-based format | Scientific Literature | |
13. | ALA4345518 | B | Substrate activity at heparanase (unknown origin) assessed as formation of saccharide hemiacetal product at 100 uM measured over 24 hrs by WST1 dye based assay | Homo sapiens | 5 | ALA4342500 | single protein format | Scientific Literature |