# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4416772 | Binding | Antagonist activity at alpha4beta2 nAChR (unknown origin) transfected in HEK cells assessed as decrease in ACh-induced intracellular calcium release incubated for 30 mins by FRET assay | Homo sapiens | 23 | ALA4414639 | cell-based format | Scientific Literature | |
2. | ALA4416773 | Binding | Antagonist activity at 5HT3A (unknown origin) transfected in HEK cells assessed as decrease in agonist-induced intracellular calcium release incubated for 30 mins by FRET assay | Homo sapiens | 23 | ALA4414639 | cell-based format | Scientific Literature | |
3. | ALA4416774 | Binding | Agonist activity at human alpha7 nAChR transfected in HEK cells assessed as increase in intracellular calcium release incubated for 30 mins in presence of PNU-120596 by FRET assay | Homo sapiens | 20 | ALA4414639 | cell-based format | Scientific Literature | |
4. | ALA4416775 | Binding | Agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in channel currents at 30 uM at -60 mV holding potential by two electrode voltage clamp assay | Homo sapiens | 4 | ALA4414639 | cell-based format | Scientific Literature | |
5. | ALA4416776 | Binding | Agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in channel currents at 30 uM at -60 mV holding potential followed washout for 181 sec and then 60 uM of Ach was applied by two electrode voltage clamp assay | Homo sapiens | 4 | ALA4414639 | cell-based format | Scientific Literature | |
6. | ALA4416777 | Binding | Agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in channel currents at -60 mV holding potential by two electrode voltage clamp assay relative Ach | Homo sapiens | 4 | ALA4414639 | cell-based format | Scientific Literature | |
7. | ALA4416778 | Binding | Inhibition of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as decrease in ACh-induced channel currents at -60 mV holding potential by two electrode voltage clamp assay | Homo sapiens | 4 | ALA4414639 | cell-based format | Scientific Literature | |
8. | ALA4416779 | Binding | Agonist activity at mouse alpha1beta1epsilondelta nAChR expressed in Xenopus laevis oocytes assessed as increase in channel currents at 30 uM at -60 mV holding potential by two electrode voltage clamp assay | Mus musculus | 4 | ALA4414639 | cell-based format | Scientific Literature | |
9. | ALA4416780 | Binding | Agonist activity at human alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as increase in channel currents at 30 uM at -60 mV holding potential by two electrode voltage clamp assay | Homo sapiens | 4 | ALA4414639 | cell-based format | Scientific Literature | |
10. | ALA4416781 | Binding | Agonist activity at human (alpha4)2 (beta2)3 nAChR expressed in Xenopus laevis oocytes assessed as increase in channel currents at 30 uM at -60 mV holding potential by two electrode voltage clamp assay | Homo sapiens | 4 | ALA4414639 | cell-based format | Scientific Literature | |
11. | ALA4416782 | Binding | Agonist activity at human (alpha4)3 (beta2)2 nAChR expressed in Xenopus laevis oocytes assessed as increase in channel currents at 30 uM at -60 mV holding potential by two electrode voltage clamp assay | Homo sapiens | 4 | ALA4414639 | cell-based format | Scientific Literature | |
12. | ALA4416783 | Binding | Inhibition of mouse alpha1beta1epsilondelta nAChR expressed in Xenopus laevis oocytes assessed as increase in channel currents at 30 uM at -60 mV holding potential by two electrode voltage clamp assay | Mus musculus | 4 | ALA4414639 | cell-based format | Scientific Literature | |
13. | ALA4416784 | Binding | Inhibition of human alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as increase in channel currents at 30 uM at -60 mV holding potential by two electrode voltage clamp assay | Homo sapiens | 4 | ALA4414639 | cell-based format | Scientific Literature | |
14. | ALA4416785 | Binding | Inhibition of human (alpha4)2 (beta2)3 nAChR expressed in Xenopus laevis oocytes assessed as increase in channel currents at 30 uM at -60 mV holding potential by two electrode voltage clamp assay | Homo sapiens | 4 | ALA4414639 | cell-based format | Scientific Literature | |
15. | ALA4416786 | Binding | Inhibition of human (alpha4)3 (beta2)2 nAChR expressed in Xenopus laevis oocytes assessed as increase in channel currents at 30 uM at -60 mV holding potential by two electrode voltage clamp assay | Homo sapiens | 4 | ALA4414639 | cell-based format | Scientific Literature | |
16. | ALA4416787 | Binding | Agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in channel currents at 30 uM at -60 mV holding potential in presence of 10 uM PNU-120596 by two electrode voltage clamp assay | Homo sapiens | 3 | ALA4414639 | cell-based format | Scientific Literature |