# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4308758 | Binding | Inhibition of His-tagged/GST-tagged LCK (unknown origin) incubated for 1 hr by TR-FRET assay | Homo sapiens | 14 | ALA4304837 | single protein format | Scientific Literature | |
2. | ALA4308759 | Binding | Inhibition of His-tagged/GST-tagged CSK (unknown origin) incubated for 1 hr by TR-FRET assay | Homo sapiens | 14 | ALA4304837 | single protein format | Scientific Literature | |
3. | ALA4308760 | Binding | Effect on ZAP70 phosphorylation in human Jurkat cells pre-incubated for 30 mins followed by anti-CD3/CD28 stimulation measured after 10 mins | Homo sapiens | 14 | ALA4304837 | cell-based format | Scientific Literature | |
4. | ALA4308761 | Binding | Effect on ZAP70 phosphorylation in human Jurkat cells pre-incubated for 30 mins followed by anti-CD3/CD28 stimulation measured after 10 mins relative to control | Homo sapiens | 13 | ALA4304837 | cell-based format | Scientific Literature | |
5. | ALA4308762 | ADME | Metabolic stability in human liver microsomes assessed as compound remaining at 0.5 uM measured after 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 14 | ALA4304837 | microsome format | Scientific Literature | |
6. | ALA4308763 | ADME | Metabolic stability in mouse liver microsomes assessed as compound remaining at 0.5 uM measured after 10 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 14 | ALA4304837 | microsome format | Scientific Literature | |
7. | ALA4308764 | Binding | Inhibition of CSK (unknown origin) using fluorescent labeled peptide as substrate in presence of ATP at Km concentration by caliper method | Homo sapiens | 8 | ALA4304837 | single protein format | Scientific Literature | |
8. | ALA4308765 | ADME | Half life in human liver microsomes at 0.5 uM measured up to 45 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4304837 | microsome format | Scientific Literature | |
9. | ALA4308766 | ADME | Half life in mouse liver microsomes at 0.5 uM measured up to 45 mins by LC-MS/MS analysis | Mus musculus | 4 | ALA4304837 | microsome format | Scientific Literature | |
10. | ALA4308767 | ADME | Protein binding in human serum assessed as unbound fraction measured up to 5 hrs by LC-MS/MS analysis relative to control | Homo sapiens | 4 | ALA4304837 | cell-free format | Scientific Literature | |
11. | ALA4308768 | ADME | Protein binding in mouse serum assessed as unbound fraction measured up to 5 hrs by LC-MS/MS analysis relative to control | Mus musculus | 4 | ALA4304837 | cell-free format | Scientific Literature |