# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4315096 | Binding | Inhibition of wildtype FLT3 (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP-FP assay | Homo sapiens | 15 | ALA4311995 | single protein format | Scientific Literature | |
2. | ALA4315097 | Binding | Inhibition of FLT3 ITD mutant (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP-FP assay | Homo sapiens | 125 | ALA4311995 | single protein format | Scientific Literature | |
3. | ALA4315098 | Binding | Inhibition of FLT3 D835Y (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP-FP assay | Homo sapiens | 15 | ALA4311995 | single protein format | Scientific Literature | |
4. | ALA4315100 | Functional | Antiproliferative activity against human MV4-11 cells harboring FLT3 ITD mutant assessed as reduction in cell viability measured after 72 hrs by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 15 | ALA4311995 | cell-based format | Scientific Literature | |
5. | ALA4315101 | Functional | Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured after 72 hrs by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 15 | ALA4311995 | cell-based format | Scientific Literature | |
6. | ALA4315102 | Functional | Antiproliferative activity against human U937 cells assessed as reduction in cell viability measured after 72 hrs by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 15 | ALA4311995 | cell-based format | Scientific Literature | |
7. | ALA4315103 | ADME | Cytotoxicity against human HS5 cells assessed as reduction in cell viability measured after 72 hrs by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 15 | ALA4311995 | cell-based format | Scientific Literature | |
8. | ALA4315104 | Physicochemical | Kinetic solubility of compound in PBS at pH 7.4 measured after 24 hrs by HPLC analysis | 13 | ALA4311995 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4315105 | Physicochemical | Kinetic solubility of compound in PBS at pH 2 measured after 24 hrs by HPLC analysis | 13 | ALA4311995 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4315106 | ADME | Permeability of compound in PBS at pH 7.4 incubated for 5 hrs by UV spectroscopic assay based PAMPA | 15 | ALA4311995 | assay format | Scientific Literature |