| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4481563 | B | Inhibition of human GAL4-fused RORgamma LBD transcriptional activity expressed in CHOK1 cells after 2 days by luciferase reporter gene assay | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
| 2. | ALA4481564 | A | Stability in human liver microsomes assessed as compound remaining after 60 mins | Homo sapiens | 27 | microsome format | Scientific Literature | ||
| 3. | ALA4481565 | P | Lipophilicity, log D of the compound | 27 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA4481567 | F | Anti-inflammatory activity in orally dosed C57BL/6 mouse model of MOG (35 to 55 residues)/pertussis toxin/anti-CD3 antibody-induced experimental allergic encephalomyelitis assessed as inhibition of IL17 production measured 8 hrs after post dose by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA4481568 | F | Anti-inflammatory activity in C57BL/6 mouse model of IL23-induced dermatitis assessed as inhibition of ear swelling at 3 to 30 mg/kg, po administered once daily from day 1 to 11 and measured on days 1, 5, 8, 10, 12 post dose | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA4481569 | B | Inhibition of GAL4-fused human RORalpha transcriptional activity expressed in CHOK1 cells after 2 days by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4481570 | B | Inhibition of GAL4-fused mouse LXR transcriptional activity expressed in CHOK1 cells after 2 days by luciferase reporter gene assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4481571 | B | Inhibition of GAL4-fused human RXR transcriptional activity expressed in CHOK1 cells after 2 days by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4481572 | B | Inhibition of GAL4-fused human PPARdelta transcriptional activity expressed in CHOK1 cells after 2 days by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4481573 | B | Inhibition of GAL4-fused human PPARgamma transcriptional activity expressed in CHOK1 cells after 2 days by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4481574 | A | Time-dependent inhibition of human CYP3A4 using midazolam as substrate | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA4481575 | A | Time-dependent inhibition of human CYP3A4 using testosterone as substrate | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA4481576 | A | Time-dependent inhibition of human CYP2C9 | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA4481577 | A | Time-dependent inhibition of human CYP2D6 | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA4481578 | A | Time-dependent inhibition of human CYP1A2 | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4481579 | A | Time-dependent inhibition of human CYP2C19 | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA4481580 | A | Terminal half life in CD(SD) rat at 1 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4481581 | A | Total body clearance in CD(SD) rat at 1 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4481582 | A | Volume of distribution at steady state in CD(SD) rat at 1 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4481583 | A | AUC in CD(SD) rat at 3 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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