# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4380649 | F | Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay | Homo sapiens | 48 | ALA4376872 | cell-based format | Scientific Literature | |
2. | ALA4380650 | F | Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay | Homo sapiens | 48 | ALA4376872 | cell-based format | Scientific Literature | |
3. | ALA4380651 | F | Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay | Homo sapiens | 48 | ALA4376872 | cell-based format | Scientific Literature | |
4. | ALA4380652 | F | Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay | Homo sapiens | 2 | ALA4376872 | cell-based format | Scientific Literature | |
5. | ALA4380653 | F | Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay | Homo sapiens | 2 | ALA4376872 | cell-based format | Scientific Literature | |
6. | ALA4380654 | F | Antiproliferative activity against human MV-3 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay | Homo sapiens | 2 | ALA4376872 | cell-based format | Scientific Literature | |
7. | ALA4380655 | F | Antiproliferative activity against human Bel7404 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay | Homo sapiens | 2 | ALA4376872 | cell-based format | Scientific Literature | |
8. | ALA4380656 | F | Antiproliferative activity against human SKHEP1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay | Homo sapiens | 2 | ALA4376872 | cell-based format | Scientific Literature | |
9. | ALA4380657 | F | Antiproliferative activity against human SW579 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay | Homo sapiens | 2 | ALA4376872 | cell-based format | Scientific Literature | |
10. | ALA4380658 | F | Antiproliferative activity against human NCI-H446 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay | Homo sapiens | 2 | ALA4376872 | cell-based format | Scientific Literature | |
11. | ALA4380659 | B | Inhibition of Escherichia coli Top1 assessed as decrease in relaxation of supercoiled pBR322 plasmid DNA at 100 uM using supercoiled pBR322 plasmid DNA as substrate incubated for 15 mins by agarose gel electrophoresis analysis | Escherichia coli | 4 | ALA4376872 | single protein format | Scientific Literature | |
12. | ALA4380660 | B | Inhibition of human Top2alpha assessed as decrease in relaxation of supercoiled pBR322 plasmid DNA at 100 uM using supercoiled pBR322 plasmid DNA as substrate incubated for 30 mins by agarose gel electrophoresis analysis | Homo sapiens | 4 | ALA4376872 | single protein format | Scientific Literature | |
13. | ALA4380661 | B | Inhibition of porcine brain tubulin polymerization measured at 1 min interval over 20 mins by absorbance based assay | Sus scrofa | 2 | ALA4376872 | assay format | Scientific Literature | |
14. | ALA4380662 | B | Inhibition of tubulin polymerization in human HCT116 cells assessed as disruption of microtubule by measuring clustered microtubule arrangement in cytosol around the nucleus at 0.4 to 10 uM incubated for 12 hrs by immunofluorescence based analysis | Homo sapiens | 1 | ALA4376872 | cell-based format | Scientific Literature | |
15. | ALA4380663 | F | Induction of apoptosis in human HCT116 cells at 0.04 uM incubated for 24 hrs by annexin V-FITC and propidium iodide staining based flow cytometry (Rvb = 0.86 %) | Homo sapiens | 1 | ALA4376872 | cell-based format | Scientific Literature | |
16. | ALA4380664 | F | Induction of apoptosis in human HCT116 cells at 0.20 uM incubated for 24 hrs by annexin V-FITC and propidium iodide staining based flow cytometry (Rvb = 0.86 %) | Homo sapiens | 1 | ALA4376872 | cell-based format | Scientific Literature | |
17. | ALA4380665 | F | Induction of apoptosis in human HCT116 cells at 1 uM incubated for 24 hrs by annexin V-FITC and propidium iodide staining based flow cytometry (Rvb = 0.86 %) | Homo sapiens | 1 | ALA4376872 | cell-based format | Scientific Literature | |
18. | ALA4380666 | F | Cell cycle arrest in human HCT116 cells assessed as accumulation in G1 phase at 4 nM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 45.18 %) | Homo sapiens | 1 | ALA4376872 | cell-based format | Scientific Literature | |
19. | ALA4380667 | F | Cell cycle arrest in human HCT116 cells assessed as accumulation in S phase at 4 nM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 42.31 %) | Homo sapiens | 1 | ALA4376872 | cell-based format | Scientific Literature | |
20. | ALA4380668 | F | Cell cycle arrest in human HCT116 cells assessed as accumulation in G2 phase at 4 nM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 12.52 %) | Homo sapiens | 1 | ALA4376872 | cell-based format | Scientific Literature |